Sequence Detail

ID/Version

Q9JIF0 Q99LS4 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Protein arginine N-methyltransferase 1 {ECO:0000305}; EC=2.1.1.319 {ECO:0000269|PubMed:15327772, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:38006878};AltName: Full=Histone-arginine N-methyltransferase PRMT1;

Provider

SWISS-PROT

Sequence

Polypeptide 371 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prmt1	protein arginine N-methyltransferase 1	114	110	4	30

Sequence references in MGI

J:61432 Pawlak MR, et al., Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable. Mol Cell Biol. 2000 Jul;20(13):4859-69
J:156247 van Dijk TB, et al., Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. Mol Cell Biol. 2010 Jan;30(1):260-72
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:267512 Murata K, et al., PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products. iScience. 2018 Oct 26;8:200-213
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:345007 Jiang C, et al., PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2. Cell Metab. 2023 Dec 5;35(12):2183-2199.e7
J:383864 Mowen KA, et al., Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell. 2004 Aug 27;15(4):559-71
J:383960 Fanis P, et al., Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Mol Cell Proteomics. 2012 Nov;11(11):1263-73
J:384066 Lai Y, et al., Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCF(Fbxl17)-recognized acetyldegron. J Cell Sci. 2017 Oct 15;130(20):3578-3587