Sequence Detail

ID/Version

Q9D6K9 Q3UL17 Q8BPH6 Q921T8 Q80YB2 Q924Z3 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Ceramide synthase 5 {ECO:0000305}; Short=CerS5 {ECO:0000305};AltName: Full=LAG1 longevity assurance homolog 5 {ECO:0000303|PubMed:16100120};AltName: Full=Sphingoid base N-palmitoyltransferase CERS5 {ECO:0000305}; EC=2.3.1.291

Provider

SWISS-PROT

Sequence

Polypeptide 414 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cers5	ceramide synthase 5	10	106	3	13

Sequence references in MGI

J:86416 Riebeling C, et al., Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different gatty acyl-CoA donors. J Biol Chem. 2003 Oct 31;278(44):43452-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117507 Lahiri S, et al., LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem. 2005 Oct 7;280(40):33735-8
J:117553 Mizutani Y, et al., Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005 Aug 15;390(Pt 1):263-71
J:124779 Mesika A, et al., A New Functional Motif in Hox Domain-containing Ceramide Synthases: IDENTIFICATION OF A NOVEL REGION FLANKING THE Hox AND TLC DOMAINS ESSENTIAL FOR ACTIVITY. J Biol Chem. 2007 Sep 14;282(37):27366-73
J:127737 Lahiri S, et al., Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett. 2007 Nov 13;581(27):5289-94
J:232428 Gosejacob D, et al., Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. J Biol Chem. 2016 Mar 25;291(13):6989-7003
J:286914 Hammerschmidt P, et al., CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell. 2019 May 30;177(6):1536-1552.e23
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89