Sequence Detail

ID/Version

Q91ZB8 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Mas-related G-protein coupled receptor member D {ECO:0000305};AltName: Full=Beta-alanine receptor {ECO:0000303|PubMed:15037633};AltName: Full=G-protein coupled receptor TGR7 {ECO:0000303|PubMed:15037633};

Provider

SWISS-PROT

Sequence

Polypeptide 321 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mrgprd	MAS-related GPR, member D	15	103	2	13

Sequence references in MGI

J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
J:94938 Zylka MJ, et al., Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 2005 Jan 6;45(1):17-25
J:269603 Oliveira AC, et al., Genetic deletion of the alamandine receptor MRGD leads to dilated cardiomyopathy in mice. Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H123-H133
J:305469 Zhang S, et al., Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis. Cell. 2021 Apr 15;184(8):2151-2166.e16
J:350526 Tetzner A, et al., G-Protein-Coupled Receptor MrgD Is a Receptor for Angiotensin-(1-7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A. Hypertension. 2016 Jul;68(1):185-94
J:359375 Lautner RQ, et al., Discovery and characterization of alamandine: a novel component of the renin-angiotensin system. Circ Res. 2013 Apr 12;112(8):1104-11
J:371286 Jesus ICG, et al., Alamandine acts via MrgD to induce AMPK/NO activation against ANG II hypertrophy in cardiomyocytes. Am J Physiol Cell Physiol. 2018 Jun 1;314(6):C702-C711
J:371329 Tetzner A, et al., Decarboxylation of Ang-(1-7) to Ala(1)-Ang-(1-7) leads to significant changes in pharmacodynamics. Eur J Pharmacol. 2018 Aug 15;833:116-123
J:371331 Yang Y, et al., Allantoin induces pruritus by activating MrgprD in chronic kidney disease. J Cell Physiol. 2023 Apr;238(4):813-828