Sequence Detail

ID/Version

Q91V01 B1B362 Q8BNH6 O35131 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Lysophospholipid acyltransferase 5; Short=LPLAT 5; EC=2.3.1.- {ECO:0000269|PubMed:18287005, ECO:0000269|PubMed:25898003};AltName: Full=1-acylglycerophosphocholine O-acyltransferase; EC=2.3.1.23 {ECO:0000269|PubMed:182

Provider

SWISS-PROT

Sequence

Polypeptide 487 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lpcat3	lysophosphatidylcholine acyltransferase 3	34	103	3	18

Sequence references in MGI

J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:206173 Rong X, et al., LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013 Nov 5;18(5):685-97
J:220827 Rong X, et al., Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 2015;4
J:229247 Hashidate-Yoshida T, et al., Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. Elife. 2015;4
J:233036 Wang B, et al., Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. Cell Metab. 2016 Mar 8;23(3):492-504
J:252691 Rong X, et al., ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest. 2017 Oct 02;127(10):3640-3651
J:271424 Wang B, et al., Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell. 2018 Feb 1;22(2):206-220.e4
J:289073 Hishikawa D, et al., Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2830-5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89