Sequence Detail

ID/Version

Q8VC56 Q4FJV7 Q9JK13 (UniProt | EBI)

Last sequence update: 2002-03-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase RNF8 {ECO:0000255|HAMAP-Rule:MF_03067}; EC=2.3.2.27 {ECO:0000255|HAMAP-Rule:MF_03067};AltName: Full=ActA-interacting protein 37; Short=AIP37;AltName: Full=LaXp180;AltName: Full=RING finger protein

Provider

SWISS-PROT

Sequence

Polypeptide 488 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rnf8	ring finger protein 8	73	98	3	8

Sequence references in MGI

J:66320 Pfeuffer T, et al., LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system, co-localizes with intracellular Listeria monocytogenes. Cell Microbiol. 2000 Apr;2(2):101-14
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:156522 Ramachandran S, et al., The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):809-14
J:159114 Lu LY, et al., RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Dev Cell. 2010 Mar 16;18(3):371-84
J:176962 Peuscher MH, et al., DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Nat Cell Biol. 2011 Sep;13(9):1139-45
J:192582 Feng L, et al., The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol. 2012 Feb;19(2):201-6
J:242565 Gou LT, et al., Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell. 2017 Jun 01;169(6):1090-1104.e13
J:244705 Wu J, et al., Chfr and RNF8 synergistically regulate ATM activation. Nat Struct Mol Biol. 2011 Jun 26;18(7):761-8
J:245385 Rai R, et al., The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol. 2011 Nov 20;18(12):1400-7
J:259113 Cardamone MD, et al., GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARgamma. Cell Rep. 2014 Jul 10;8(1):163-76