Sequence Detail

ID/Version

Q8R4B8 Q1JQ87 Q6JEL0 Q1JQ88 T1W2H6 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=NACHT, LRR and PYD domains-containing protein 3 {ECO:0000305}; EC=3.6.4.- {ECO:0000269|PubMed:34861190};AltName: Full=Cold autoinflammatory syndrome 1 protein homolog {ECO:0000303|PubMed:15302403};AltName: Full=Cryopyrin {ECO:0000303

Provider

SWISS-PROT

Sequence

Polypeptide 1033 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlrp3	NLR family, pyrin domain containing 3	122	99	93	42

Sequence references in MGI

J:92340 Anderson JP, et al., Structural, expression, and evolutionary analysis of mouse CIAS1. Gene. 2004 Aug 18;338(1):25-34
J:106976 Mariathasan S, et al., Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006 Mar 9;440(7081):228-32
J:113333 Sutterwala FS, et al., Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 2006 Mar;24(3):317-27
J:117613 Kanneganti TD, et al., Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem. 2006 Dec 1;281(48):36560-8
J:124226 Martinon F, et al., Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006 Mar 9;440(7081):237-41
J:133267 Kanneganti TD, et al., Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature. 2006 Mar 9;440(7081):233-6
J:147962 Allen IC, et al., The NLRP3 inflammasome mediates in vivo innate immunity to influenza a virus through recognition of viral RNA. Immunity. 2009 Apr;30(4):556-65
J:164216 Lamkanfi M, et al., Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol. 2010 Oct 1;185(7):4385-92
J:186690 Lu B, et al., Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 30;488(7413):670-4
J:196452 Misawa T, et al., Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 2013 May;14(5):454-60
J:197368 Subramanian N, et al., The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell. 2013 Apr 11;153(2):348-61
J:207575 Yan Y, et al., Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013 Jun 27;38(6):1154-63
J:207576 Munoz-Planillo R, et al., K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 2013 Jun 27;38(6):1142-53
J:224866 Bruchard M, et al., The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015 Aug;16(8):859-70
J:226677 Shi H, et al., NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol. 2016 Mar;17(3):250-8
J:228574 Schmid-Burgk JL, et al., A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation. J Biol Chem. 2016 Jan 1;291(1):103-9
J:229240 He Y, et al., NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. 2016 Feb 18;530(7590):354-7
J:234642 Wolf AJ, et al., Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell. 2016 Jul 28;166(3):624-36
J:234957 Spalinger MR, et al., NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. J Clin Invest. 2016 May 2;126(5):1783-800
J:243237 Song H, et al., The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3. Nat Commun. 2016 Dec 08;7:13727
J:244223 Zhang Z, et al., Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017 Sep 04;214(9):2671-2693
J:249560 Li X, et al., MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Nat Commun. 2017 Jun 28;8:15986
J:251887 Song N, et al., NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Mol Cell. 2017 Oct 5;68(1):185-197.e6
J:253629 Nakanishi H, et al., NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7766-E7775
J:267662 Chen J, et al., PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature. 2018 Dec;564(7734):71-76
J:268399 Hafner-Bratkovic I, et al., NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat Commun. 2018 Dec 5;9(1):5182
J:279977 Samir P, et al., DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019 Sep;573(7775):590-594
J:313326 Pan P, et al., SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. Nat Commun. 2021 Aug 2;12(1):4664
J:313659 Niu T, et al., NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly. Nat Commun. 2021 Oct 6;12(1):5862
J:331359 Py BF, et al., Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell. 2013 Jan 24;49(2):331-8
J:331464 Dostert C, et al., Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 2008 May 2;320(5876):674-7
J:331916 Andreeva L, et al., NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell. 2021 Dec 22;184(26):6299-6312.e22
J:331917 Stutz A, et al., NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med. 2017 Jun 5;214(6):1725-1736
J:331919 Bittner ZA, et al., BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. J Exp Med. 2021 Nov 1;218(11):e20201656
J:334741 Zhu F, et al., The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity. 2023 Apr 11;56(4):753-767.e8