Sequence Detail

ID/Version

Q8QZY3 F6S6F5 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Developmental pluripotency-associated protein 3;AltName: Full=Compaction-associated protein 1;AltName: Full=Primordial germ cell protein 7 {ECO:0000303|PubMed:11900980};AltName: Full=Stella {ECO:0000303|PubMed:12124616};

Provider

SWISS-PROT

Sequence

Polypeptide 150 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dppa3	developmental pluripotency-associated 3	17	136	5	35

Sequence references in MGI

J:76228 Sato M, et al., Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells. Mech Dev. 2002 Apr;113(1):91-4
J:78127 Saitou M, et al., A molecular programme for the specification of germ cell fate in mice. Nature. 2002 Jul 18;418(6895):293-300
J:82465 Bortvin A, et al., Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development. 2003 Apr;130(8):1673-80
J:86824 Payer B, et al., stella is a maternal effect gene required for normal early development in mice. Curr Biol. 2003 Dec 2;13(23):2110-7
J:87105 Bowles J, et al., Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. Cytogenet Genome Res. 2003;101(3-4):261-5
J:93295 Bortvin A, et al., Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. BMC Dev Biol. 2004 Mar 23;4(1):2
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:185777 Liu YJ, et al., Essential role of DPPA3 for chromatin condensation in mouse oocytogenesis. Biol Reprod. 2012 Feb;86(2):40
J:186710 Nakamura T, et al., PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature. 2012 Jun 21;486(7403):415-9
J:189990 Nakamura T, et al., PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat Cell Biol. 2007 Jan;9(1):64-71
J:192647 Wossidlo M, et al., 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun. 2011;2:241