Sequence Detail

ID/Version

Q8K0L0 Q9CTH4 Q9WV73 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Ankyrin repeat and SOCS box protein 2; Short=ASB-2;

Provider

SWISS-PROT

Sequence

Polypeptide 634 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Asb2	ankyrin repeat and SOCS box-containing 2	36	107	4	11

Sequence references in MGI

J:66288 Kile BT, et al., Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins asb-1, asb-2, asb-3 and asb-4. Gene. 2000 Nov 27;258(1-2):31-41
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:164183 Bello NF, et al., The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation. Cell Death Differ. 2009 Jun;16(6):921-32
J:200966 Lamsoul I, et al., ASB2alpha regulates migration of immature dendritic cells. Blood. 2013 Jul 25;122(4):533-41
J:251576 Thottakara T, et al., The E3 ubiquitin ligase Asb2beta is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation. J Mol Cell Cardiol. 2015 Oct;87:214-24
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306591 Davey JR, et al., Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass. JCI Insight. 2016 Apr 21;1(5):e85477
J:306640 Yamak A, et al., Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle. iScience. 2020 Mar 27;23(3):100959
J:306706 Metais A, et al., Asb2alpha-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development. Circ Res. 2018 Mar 16;122(6):e34-e48