Sequence Detail

ID/Version

Q8CIP3 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Mas-related G-protein coupled receptor member X1;AltName: Full=Mas-related G-protein coupled receptor member C11 {ECO:0000303|PubMed:12397184};AltName: Full=Sensory neuron-specific G-protein coupled receptor 1;

Provider

SWISS-PROT

Sequence

Polypeptide 322 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mrgprx1	MAS-related GPR, member X1	15	96	4	7

Sequence references in MGI

J:87341 Han SK, et al., Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14740-5
J:157470 Liu Q, et al., Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009 Dec 24;139(7):1353-65
J:224443 Reddy VB, et al., Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. Nat Commun. 2015;6:7864
J:304844 Steele HR, et al., MrgprC11(+) sensory neurons mediate glabrous skin itch. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2022874118
J:329699 Li X, et al., Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors. J Allergy Clin Immunol. 2021 Jun;147(6):2236-2248.e16
J:359444 Jiang H, et al., Divergent sensory pathways of sneezing and coughing. Cell. 2024 Oct 17;187(21):5981-5997.e14
J:371288 Sanjel B, et al., BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci Rep. 2019 Jul 26;9(1):10888