Sequence Detail

ID/Version

Q6PDX6 Q3T9M4 Q8JZY5 A2APP0 Q3V3D7 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase Rnf220; EC=2.3.2.27 {ECO:0000269|PubMed:31291587};AltName: Full=RING finger protein 220;AltName: Full=RING-type E3 ubiquitin transferase Rnf220 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 566 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rnf220	ring finger protein 220	52	104	4	178

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:162970 Kong Q, et al., RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination. Biochem Biophys Res Commun. 2010 Mar 19;393(4):708-13
J:286599 Song NN, et al., Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Development. 2020 Mar 30;147(6):dev185199
J:291960 Ma P, et al., Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Rep. 2019 Jul 9;28(2):541-553.e4
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319816 Guo X, et al., RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense. Cell Death Differ. 2021 Feb;28(2):640-656
J:329945 Ma P, et al., RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission. Sci Adv. 2022 Sep 30;8(39):eabq4736