Sequence Detail

ID/Version

Q62231 Q8CIL7 (UniProt | EBI)

Last sequence update: 2004-04-13
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Homeobox protein SIX1;AltName: Full=Sine oculis homeobox homolog 1;

Provider

SWISS-PROT

Sequence

Polypeptide 284 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Six1	sine oculis-related homeobox 1	126	162	4	39

Sequence references in MGI

J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
J:51236 Spitz F, et al., Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14220-5
J:82459 Laclef C, et al., Altered myogenesis in Six1-deficient mice. Development. 2003 May;130(10):2239-52
J:83432 Xu PX, et al., Six1 is required for the early organogenesis of mammalian kidney. Development. 2003 Jul;130(14):3085-94
J:84417 Laclef C, et al., Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. Mech Dev. 2003 Jun;120(6):669-79
J:86619 Li X, et al., Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20;426(6964):247-54
J:90664 Ruf RG, et al., SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8090-5
J:104488 Ozaki H, et al., Six1 controls patterning of the mouse otic vesicle. Development. 2004 Feb;131(3):551-62
J:178379 Richard AF, et al., Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
J:212814 Ikeda K, et al., Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. Mol Cell Biol. 2002 Oct;22(19):6759-66
J:237490 Brunmeir R, et al., Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PLoS Genet. 2016 Dec;12(12):e1006474