Sequence Detail

ID/Version

Q62219 Q3YBY7 Q3YBZ6 Q3YBZ4 Q3YBZ5 Q3YBZ3 Q3YBZ0 Q3YBZ1 Q3YBY8 (UniProt | EBI)

Last sequence update: 2007-06-26
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Transforming growth factor beta-1-induced transcript 1 protein;AltName: Full=Androgen receptor-associated protein of 55 kDa;AltName: Full=Hydrogen peroxide-inducible clone 5 protein; Short=Hic-5;AltName: Full=TGF beta-stimulated clon

Provider

SWISS-PROT

Sequence

Polypeptide 461 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tgfb1i1	transforming growth factor beta 1 induced transcript 1	40	110	2	5

Sequence references in MGI

J:21116 Shibanuma M, et al., Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence. J Biol Chem. 1994 Oct 28;269(43):26767-74
J:45163 Matsuya M, et al., Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. J Biol Chem. 1998 Jan 9;273(2):1003-14
J:54072 Nishiya N, et al., Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain. J Biol Chem. 1999 Apr 2;274(14):9847-53
J:62531 Mashimo J, et al., Genomic structure and chromosomal mapping of the mouse hic-5 gene that encodes a focal adhesion protein. Gene. 2000 May 16;249(1-2):99-103
J:67663 Nikolopoulos SN, et al., Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion. J Cell Biol. 2000 Dec 25;151(7):1435-48
J:70363 Brunskill EW, et al., Novel cell lines promote the discovery of genes involved in early heart development. Dev Biol. 2001 Jul 15;235(2):507-20
J:72349 Jia Y, et al., Identification and characterization of hic-5/ARA55 as an hsp27 binding protein. J Biol Chem. 2001 Oct 26;276(43):39911-8
J:95883 Drori S, et al., Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 1;19(3):362-75
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104458 Hetey SE, et al., Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation. Exp Cell Res. 2005 Nov 15;311(1):147-56
J:116475 Mori K, et al., Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex. J Biol Chem. 2006 Aug 4;281(31):22048-61
J:121675 Rathore VB, et al., Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem J. 2007 Apr 15;403(2):275-81
J:143699 Fujita H, et al., Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase. J Biol Chem. 1998 Oct 9;273(41):26516-21
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89