Sequence Detail

ID/Version

Q61115 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Protein patched homolog 1 {ECO:0000303|PubMed:8595881}; Short=PTC; Short=PTC1;

Provider

SWISS-PROT

Sequence

Polypeptide 1434 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptch1	patched 1	143	414	4	54

Sequence references in MGI

J:31336 Goodrich LV, et al., Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 1996 Feb 1;10(3):301-12
J:42441 Goodrich LV, et al., Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 1997 Aug 22;277(5329):1109-13
J:123161 Rohatgi R, et al., Patched1 regulates hedgehog signaling at the primary cilium. Science. 2007 Jul 20;317(5836):372-6
J:180534 Bidet M, et al., The hedgehog receptor patched is involved in cholesterol transport. PLoS One. 2011;6(9):e23834
J:200497 Ma G, et al., Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Res. 2011 Sep;21(9):1343-57
J:201190 Marazziti D, et al., Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16486-16491
J:224341 Chen XL, et al., Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog. Mol Cell Biol. 2014 Oct;34(20):3855-66
J:236394 Roberts B, et al., Patched1 and Patched2 inhibit Smoothened non-cell autonomously. Elife. 2016 Aug 23;5:e17634
J:251890 Xiao X, et al., Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling. Mol Cell. 2017 Apr 6;66(1):154-162.e10
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:382819 Yue S, et al., Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception. Elife. 2014 Jun 12;3
J:382827 Zhang Y, et al., Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28838-28846
J:382880 Weiss LE, et al., Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5550-5557
J:382886 Kinnebrew M, et al., Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Sci Adv. 2022 Jun 3;8(22):eabm5563
J:383014 Taipale J, et al., Patched acts catalytically to suppress the activity of Smoothened. Nature. 2002 Aug 22;418(6900):892-7
J:383071 Zhang Y, et al., Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched. Cell. 2018 Nov 15;175(5):1352-1364.e14