Sequence Detail

ID/Version

Q60769 Q3U968 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Tumor necrosis factor alpha-induced protein 3; Short=TNF alpha-induced protein 3; EC=2.3.2.-; EC=3.4.19.12;AltName: Full=Putative DNA-binding protein A20;AltName: Full=Zinc finger protein A20;

Provider

SWISS-PROT

Sequence

Polypeptide 775 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tnfaip3	tumor necrosis factor, alpha-induced protein 3	103	100	3	33

Sequence references in MGI

J:43379 Tewari M, et al., Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J Immunol. 1995 Feb 15;154(4):1699-706
J:64942 Heyninck K, et al., The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J Cell Biol. 1999 Jun 28;145(7):1471-82
J:92694 Boone DL, et al., The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol. 2004 Oct;5(10):1052-60
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:132994 Hitotsumatsu O, et al., The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity. 2008 Mar;28(3):381-90
J:196955 Li Y, et al., Immune Responsive Gene 1 (IRG1) Promotes Endotoxin Tolerance by Increasing A20 Expression in Macrophages through Reactive Oxygen Species. J Biol Chem. 2013 Jun 7;288(23):16225-34