Sequence Detail

ID/Version

Q5XJV7 Q80T94 Q8BX30 Q8BKD5 (UniProt | EBI)

Last sequence update: 2007-04-03
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase SETD5 {ECO:0000305}; EC=2.1.1.359 {ECO:0000269|PubMed:31515109}; EC=2.1.1.367 {ECO:0000305|PubMed:22939622};AltName: Full=SET domain-containing protein 5 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 1441 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Setd5	SET domain containing 5	24	102	3	132

Sequence references in MGI

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:237500 Osipovich AB, et al., Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Development. 2016 Dec 15;143(24):4595-4607
J:269562 Pinheiro I, et al., Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell. 2012 Aug 31;150(5):948-60
J:271411 Deliu E, et al., Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. Nat Neurosci. 2018 Dec;21(12):1717-1727
J:282587 Sessa A, et al., SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring. Neuron. 2019 Oct 23;104(2):271-289.e13
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298770 Moore SM, et al., Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice. Transl Psychiatry. 2019 Jan 17;9(1):24