Sequence Detail

ID/Version

Q4KUS2 E9QKH9 Q3UHG2 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Protein unc-13 homolog A {ECO:0000305};AltName: Full=Munc13-1 {ECO:0000303|PubMed:23229896};

Provider

SWISS-PROT

Sequence

Polypeptide 1712 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Unc13a	unc-13 homolog A	78	99	3	19

Sequence references in MGI

J:56513 Augustin I, et al., Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. Nature. 1999 Jul 29;400(6743):457-61
J:77339 Varoqueaux F, et al., Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9037-42
J:99336 Varoqueaux F, et al., Aberrant morphology and residual transmitter release at the munc13-deficient mouse neuromuscular synapse. Mol Cell Biol. 2005 Jul;25(14):5973-84
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108689 Kwan EP, et al., Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes. 2006 May;55(5):1421-9
J:117827 Basu J, et al., Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion. J Neurosci. 2007 Jan 31;27(5):1200-10
J:126559 Kwan EP, et al., Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells. Diabetes. 2007 Oct;56(10):2579-88
J:129644 Kang L, et al., Munc13-1 is required for the sustained release of insulin from pancreatic beta cells. Cell Metab. 2006 Jun;3(6):463-8
J:159767 Tada H, et al., Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. J Biol Chem. 2010 Feb 5;285(6):3840-9
J:195236 van de Bospoort R, et al., Munc13 controls the location and efficiency of dense-core vesicle release in neurons. J Cell Biol. 2012 Dec 10;199(6):883-91
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89