Sequence Detail

ID/Version

Q3UP87 A6H698 Q61515 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Neutrophil elastase {ECO:0000303|PubMed:8035830}; EC=3.4.21.37 {ECO:0000250|UniProtKB:P08246};AltName: Full=Elastase-2;AltName: Full=Leukocyte elastase;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 265 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Elane	elastase, neutrophil expressed	101	98	2	19

Sequence references in MGI

J:61604 Nuchprayoon I, et al., PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol. 1994 Aug;14(8):5558-68
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:163317 Massberg S, et al., Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med. 2010 Aug;16(8):887-96
J:166722 Papayannopoulos V, et al., Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol. 2010 Nov 1;191(3):677-91
J:380139 Okeke EB, et al., Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock. Biomaterials. 2020 Apr;238:119836