Sequence Detail

ID/Version

Q3ULF4 Q7TNG0 B2RQY8 Q4V9T9 D3Z1Z1 Q8R1A1 Q80X42 Q8K414 Q811Y5 Q8R1K2 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Paraplegin {ECO:0000303|PubMed:14722615}; EC=3.4.24.-;AltName: Full=Spastic paraplegia 7 protein {ECO:0000312|MGI:MGI:2385906};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 781 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Spg7	SPG7, paraplegin matrix AAA peptidase subunit	25	98	3	7

Sequence references in MGI

J:87616 Ferreirinha F, et al., Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport. J Clin Invest. 2004 Jan;113(2):231-42
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117691 Koppen M, et al., Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia. Mol Cell Biol. 2007 Jan;27(2):758-67
J:164484 Koppen M, et al., Autocatalytic processing of m-AAA protease subunits in mitochondria. Mol Biol Cell. 2009 Oct;20(19):4216-24
J:187268 Mancuso G, et al., Alternative splicing of Spg7, a gene involved in hereditary spastic paraplegia, encodes a variant of paraplegin targeted to the endoplasmic reticulum. PLoS One. 2012;7(5):e36337
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89