Sequence Detail

ID/Version

Q01721 (UniProt | EBI)

Last sequence update: 2003-05-16
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Growth arrest-specific protein 1 {ECO:0000303|PubMed:1505026}; Short=GAS-1 {ECO:0000303|PubMed:1505026};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 343 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gas1	growth arrest specific 1	72	135	4	11

Sequence references in MGI

J:41311 Del Sal G, et al., The growth arrest-specific gene, gas1, is involved in growth suppression. Cell. 1992 Aug 21;70(4):595-607
J:64788 Stebel M, et al., The growth suppressing gas1 product is a GPI-linked protein. FEBS Lett. 2000 Sep 15;481(2):152-8
J:70735 Lee CS, et al., Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant. Dev Biol. 2001 Aug 1;236(1):17-29
J:71832 Lee CS, et al., Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11347-52
J:79482 Liu Y, et al., growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development. 2002 Nov;129(22):5289-300
J:121554 Martinelli DC, et al., Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 2007 May 15;21(10):1231-43
J:173604 Allen BL, et al., Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function. Dev Cell. 2011 Jun 14;20(6):775-87
J:343398 Cheng YS, et al., A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes. Nat Chem Biol. 2021 Dec;17(12):1271-1280
J:382884 Wierbowski BM, et al., Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand. Dev Cell. 2020 Nov 23;55(4):450-467.e8