Sequence Detail

ID/Version

P97363 P97356 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Serine palmitoyltransferase 2 {ECO:0000305}; EC=2.3.1.50 {ECO:0000250|UniProtKB:O15270};AltName: Full=Long chain base biosynthesis protein 2; Short=LCB 2;AltName: Full=Long chain base biosynthesis protein 2a; Short=LC

Provider

SWISS-PROT

Sequence

Polypeptide 560 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sptlc2	serine palmitoyltransferase, long chain base subunit 2	38	100	4	245

Sequence references in MGI

J:36511 Nagiec MM, et al., Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase. Gene. 1996 Oct 24;177(1-2):237-41
J:43725 Weiss B, et al., Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur J Biochem. 1997 Oct 1;249(1):239-47
J:247919 Lee SY, et al., Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. Diabetes. 2017 Oct;66(10):2596-2609
J:255961 Chaurasia B, et al., Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism. Cell Metab. 2016 Dec 13;24(6):820-834
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89