Sequence Detail

ID/Version

P42580 Q9JKX0 A4QPC3 Q9JKW6 Q9JKW5 Q9JKX1 Q9JKW9 Q9JHF2 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=NK1 transcription factor-related protein 2;AltName: Full=Homeobox protein SAX-1 {ECO:0000303|PubMed:7669696};AltName: Full=NKX-1.1;

Provider

SWISS-PROT

Sequence

Polypeptide 305 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nkx1-2	NK1 homeobox 2	13	122	3	10

Sequence references in MGI

J:26182 Schubert FR, et al., Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech Dev. 1995 May;51(1):99-114
J:43927 Hong SB, et al., Identification of the transcription termination site of the mouse nkx-1.2 gene: involvement of sequence-specific factors. Gene. 1997 Oct 1;198(1-2):373-8
J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
J:60862 Rovescalli AC, et al., The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):1982-7
J:283048 Chen N, et al., The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation. J Biol Chem. 2019 Nov 29;294(48):18408-18420
J:348701 Nakagawa S, et al., The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development. Stem Cell Reports. 2024 May 14;19(5):689-709