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Sequence Detail
O88705 (UniProt | EBI) Last sequence update: 1998-11-01
Last annotation update: 2024-05-29
from provider
RecName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3;AltName: Full=Hyperpolarization-activated cation channel 3; Short=HAC-3;
Polypeptide 779 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Hcn3 hyperpolarization-activated, cyclic nucleotide-gated K+ 3 27 107 3 6
Sequence references in MGI J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
J:48083 Ludwig A, et al., A family of hyperpolarization-activated mammalian cation channels. Nature. 1998 Jun 11;393(6685):587-91
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100888 Mistrik P, et al., The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. J Biol Chem. 2005 Jul 22;280(29):27056-61
J:203510 Cao-Ehlker X, et al., Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). J Biol Chem. 2013 Mar 15;288(11):7580-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory