Sequence Detail

ID/Version

O88662 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Epithelial membrane protein 2; Short=EMP-2;AltName: Full=Protein XMP;

Provider

SWISS-PROT

Sequence

Polypeptide 172 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Emp2	epithelial membrane protein 2	80	100	3	12

Sequence references in MGI

J:47934 Ben-Porath I, et al., Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22. Genomics. 1998 May 1;49(3):443-7
J:91398 Wadehra M, et al., The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins. Mol Biol Cell. 2004 May;15(5):2073-83
J:103508 Wadehra M, et al., Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Dev Biol. 2005 Nov 15;287(2):336-45
J:109419 Wadehra M, et al., Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse. Dev Biol. 2006 Apr 15;292(2):430-41
J:124656 Forbes A, et al., The Tetraspan Protein EMP2 Regulates Expression of Caveolin-1. J Biol Chem. 2007 Sep 7;282(36):26542-51
J:215657 Wadehra M, et al., The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death. Clin Immunol. 2003 May;107(2):129-36
J:215661 Wadehra M, et al., The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J Biol Chem. 2002 Oct 25;277(43):41094-100
J:215886 Wadehra M, et al., Steroid hormone regulation of EMP2 expression and localization in the endometrium. Reprod Biol Endocrinol. 2008;6:15
J:243365 Williams CJ, et al., Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. J Pathol. 2017 Jun;242(2):246-259
J:293323 Lin WC, et al., Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace. J Clin Invest. 2020 Jan 2;130(1):157-170
J:319835 Liu Y, et al., Loss of Emp2 compromises cardiogenic differentiation in mouse embryonic stem cells. Biochem Biophys Res Commun. 2019 Mar 26;511(1):173-178