Sequence Detail

ID/Version

O70200 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Allograft inflammatory factor 1; Short=AIF-1;AltName: Full=Ionized calcium-binding adapter molecule 1;

Provider

SWISS-PROT

Sequence

Polypeptide 147 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Aif1	allograft inflammatory factor 1	83	131	2	14

Sequence references in MGI

J:72558 Watano K, et al., Allograft inflammatory factor-1 augments production of interleukin-6, -10 and -12 by a mouse macrophage line. Immunology. 2001 Nov;104(3):307-16
J:86796 Xie T, et al., Analysis of the gene-dense Major Histocompatibility Complex class III region and its comparison to mouse. Genome Res. 2003 Dec;13(12):2621-36
J:90132 Ohsawa K, et al., Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity. J Neurochem. 2004 Feb;88(4):844-56
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:182386 Yamada M, et al., X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding. J Mol Biol. 2006 Dec 1;364(3):449-57
J:182420 Ohsawa K, et al., Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J Cell Sci. 2000 Sep;113(Pt 17):3073-84
J:269679 Sasaki Y, et al., Iba1 is an actin-cross-linking protein in macrophages/microglia. Biochem Biophys Res Commun. 2001 Aug 17;286(2):292-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89