Sequence Detail

ID/Version

O08967 Q8CI93 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Cytohesin-3;AltName: Full=ARF nucleotide-binding site opener 3; Short=Protein ARNO3;AltName: Full=General receptor of phosphoinositides 1; Short=Grp1;AltName: Full=PH, SEC7 and coiled-coil domain-containing protein 3;

Provider

SWISS-PROT

Sequence

Polypeptide 399 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cyth3	cytohesin 3	22	99	4	8

Sequence references in MGI

J:39322 Klarlund JK, et al., Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains [see comments]. Science. 1997 Mar 28;275(5308):1927-30
J:49556 Kim HS, et al., Complex regulation of multiple cytohesin-like genes in murine tissues and cells. FEBS Lett. 1998 Aug 21;433(3):312-6
J:62592 Nevrivy DJ, et al., Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. J Biol Chem. 2000 Jun 2;275(22):16827-36
J:70309 Korthauer U, et al., Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family. J Immunol. 2000 Jan 1;164(1):308-18
J:156525 Ikenouchi J, et al., FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):748-53
J:202589 DiNitto JP, et al., Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell. 2007 Nov 30;28(4):569-83
J:202590 Cronin TC, et al., Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J. 2004 Oct 1;23(19):3711-20
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89