Sequence Detail

ID/Version

A2AAJ9 B2FDE7 Q695L2 A2AB85 Q811H7 (UniProt | EBI)

Last sequence update: 2019-04-10
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Obscurin; EC=2.7.11.1 {ECO:0000269|PubMed:23392350};AltName: Full=Obscurin-RhoGEF;AltName: Full=Obscurin-myosin light chain kinase; Short=Obscurin-MLCK;

Provider

SWISS-PROT

Sequence

Polypeptide 8886 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Obscn	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	45	98	4	9

Sequence references in MGI

J:91783 Caenepeel S, et al., The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11707-12
J:91843 Sutter SB, et al., Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases. Dev Genes Evol. 2004 Jul;214(7):352-9
J:197851 Hu LY, et al., The kinase domains of obscurin interact with intercellular adhesion proteins. FASEB J. 2013 May;27(5):2001-12
J:281255 Ackermann MA, et al., Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway. J Mol Cell Cardiol. 2017 Oct;111:27-39
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89