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Pou4f3tm1.1(cre)Tcba - Head
Recombinase Activity Detail
Allele Information
Allele:
Pou4f3tm1.1(cre)Tcba
POU domain, class 4, transcription factor 3; targeted mutation 1.1, Tudor Constantin Badea 		Driver: Pou4f3
Type: Targeted (Conditional ready, Recombinase)
Synonym: Brn3cCKOCre
Molecular description: The targeting consists of a FREX cassette (containing the rox12 and roxP target sites for the Dre recombinase in direct orientation, separated by a 68 bp spacer) inserted in the 5' untranslated region (UTR) of the Pou4f3 locus, 65 bp before the initiator codon ATG; three repeats of the SV40 early region transcription terminator inserted in the 3' UTR, 564 bp downstream of the STOP codon; the Cre recombinase cDNA in reverse orientation and a second FREX cassette in reverse orientation; and the Neomycin positive selection cassette (PGKNeo) flanked by FRT (Flp recombinase target) sites. The targeting vector was introduced to 129-derived R1 embryonic stem cells. The neomycin cassette was excised with a germline FLP recombinase.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Pou4f3tm1.1(cre)Tcba activity also observed in:
sensory organs
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:322005 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory