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Aldh1a1em2(cre)Ylu - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Aldh1a1em2(cre)Ylu
aldehyde dehydrogenase family 1, subfamily A1; endonuclease-mediated mutation 2, Youming Lu 		Driver: Aldh1a1
Type: Endonuclease-mediated (Null/knockout, Recombinase)
Synonym: Aldh1a1-/--CRE
Molecular description: Using CRISPR/Cas9 system, P2A-CRE-pA was inserted downstream of exon 10 of the Aldh1a1 gene. The premature termination of the transcript deleted the exons 1113 corresponding to the 100 amino acids (401-500) of the C-terminal, which is essential for enzyme function and stability of Aldh1a1. It is a null allele. The absence of protein products was established by western blot analysis.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Aldh1a1em2(cre)Ylu activity also observed in:
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Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory