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Allele Information
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Allele:
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Tg(Msx2-cre/ERT2)1Nono
transgene insertion 1, Noriaki Ono
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Driver: Msx2
Type: Transgenic
(Inducible, Recombinase)
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Inducer:
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tamoxifen
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Synonym:
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Molecular description:
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The approximately 180kb RP23-438B5 mouse bacterial artificial chromosome (BAC) containing the entire mouse Msx2 gene (and 139kb upstream and 32 kb downstream flanking sequences) was modified by inserting a cre/ERT2 coding sequence, a FRT site flanked neo, and a SV40 polyadenylation signal sequence, into the first exon of the Msx2 gene, replacing the initiation ATG codon. The FRT site flanked neo was removed by transient FLP recombinase induction. DNA from a correctly modified BAC clone was used as the source for the Msx2-creER-SV40pA transgene was microinjected into the pronucleus of fertilized oocytes from hybrid SJL X C57BL/6 mice. Two independent founder lines 1 and 2 were established, and line 2 expressing higher cre/ER gene was used for analyses.
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Find mice (IMSR):
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Mouse Strains:
0 strains available
Cell Lines:
0 lines available
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Tissue Information
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Integumental System
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Other recombinase alleles with activity in Integumental System tissues:
Agrptm1(cre)Lowl,
Airetm3(cre)Mmat,
Alpltm1(cre)Nagy,
Atoh8tm1(EGFP/cre)Gasa,
Axin2tm1(cre/ERT2)Rnu,
Bcl11atm1.1(cre/ERT2)Khal,
Cacna1htm2.1(cre)Glwn,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cdkn2atm1(cre/ERT2)Mkt,
Chattm2(cre)Lowl,
Cldn6tm1(cre/ERT2)Dam,
Clec9atm2.1(icre)Crs,
Clutm2(EGFP/cre/ERT2)Wtsi,
Commd10Tg(Vav1-icre)A2Kio,
Corintm2(cre)Bamo,
Crhtm1(cre)Zjh,
Cx3cr1tm2.1(cre/ERT2)Litt,
Dctem1(cre/ERT2)Enis,
Dcttm1(cre)Bee,
Dkk1tm1(cre/ERT2)Pmy,
Dpttm1.1(cre/ERT2)Snjt,
E2f1Tg(Wnt1-cre)2Sor,
Emx1tm1(cre)Krj,
En1tm2(cre)Wrst,
Epxtm1.1(cre)Jlee,
Foxd1tm1(GFP/cre)Amc,
Gad2tm2(cre)Zjh,
Gfi1tm1(cre)Gan,
Ghem1(cre)Jmz,
Giprem1(icre)Reim,
Gli1tm3(cre/ERT2)Alj,
Glp1rtm1.1(cre)Cors,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc,
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm1(cre/ERT)Brn,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Gt(ROSA)26Sortm5(dre)Dwi,
Gt(ROSA)26Sortm6(dre/PGR*)Dwi,
Gt(ROSA)26Sortm8(CAG-dre/ERT2)Bzsh,
H2az2Tg(Wnt1-cre)11Rth,
Hoxc8tm2.1(cre)Mrc,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Hsd11b2tm1(cre)Anft,
Ifi208Tg(Cspg4-cre)1Akik,
Ihhem1(Tomm20/mKate2,dre)Xya,
Kittm1.1(cre)Jmol,
Kittm1(cre/ERT2)Bzsh,
Kittm2.1(cre/Esr1*)Jmol,
Krt14tm1.1(cre/ERT2)Hjg,
Krt14tm1.1(cre)Wbm,
Krt14tm1(cre)Wbm,
Krt17tm1(cre)Murr,
Krt6aem1(icre)Vk,
Leprem2(cre/ERT2)Smoc,
Leprtm2(cre)Rck,
Lgr5em1(cre/ERT2)Kba,
Lgr5tm1.1(cre/ERT2)Npa,
Lgr5tm1(cre/ERT2)Cle,
Lgr6tm2.1(cre/ERT2)Cle,
Lrig1tm1.1(cre/ERT2)Rjc,
Lrig1tm1(cre/ERT2)Kjen,
Lrig1tm2.1(icre/ERT2)Mrc,
Ltftm1(icre)Tdku,
Lyve1tm1.1(EGFP/cre)Cys,
Mcm2tm1(cre/ERT2)Scpr,
Megf6em3(cre)Zzhg,
Mnx1tm4(cre)Tmj,
Mrgprdtm1.1(cre/ERT2)Wql,
Myf5tm3(cre)Sor,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Nkx2-5tm2(cre)Rph,
Notch1tm3(cre)Rko,
Oca2tm1(cre/ERT2)Mymi,
Omptm4(cre)Mom,
Opn3em1(cre)Lan,
Opn5em1(cre)Lan,
Osr2tm2(cre)Jian,
Oxtrtm3.1(Oxtr*,cre)Knis,
Pax3tm1.1(cre/ERT2)Lepr,
Pax3tm1(cre)Joe,
Pbx3tm1(EGFP/cre/ERT2)Wtsi,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pdgfratm2.2(flpo)Leol,
Pdgfrbtm1.2(flpo)Leol,
Piezo2tm1.1(cre)Apat,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Pmelem1(rtTA,tetO-icre)Osaw,
Prdm1tm3(icre)Rob,
Prdm1tm5.1(cre/ERT2)Rob,
Prlrtm1.1(cre)Uboe,
Procrtm1.1(cre/ERT2)Yaz,
Pvalbtm1(cre)Arbr,
Scn9aem1(icre)Itsu,
Shhtm1(EGFP/cre)Cjt,
Shhtm2(cre/ERT2)Cjt,
Slc17a6tm2(cre)Lowl,
Smoc2tm1(cre/ERT2)Cle,
Sox9em1(cre/ERT2)Tchn,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tbx3em1(cre/ERT2)Toyo,
Tcf7l1tm1.1(cre/ERT2)Hng,
Tg(ACTA1-cre)1Mll,
Tg(ACTA1-cre)79Jme,
Tg(Actl6b-cre)4092Jiwu,
Tg(Adipoq-cre)1Evdr,
Tg(Aire-cre)410-5Mmat,
Tg(Bmx-cre/ERT2)1Rha,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Camk2a-cre)1Nobs,
Tg(CD2-icre)4Kio,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Cdx2-cre)R337Npln,
Tg(Ckmm-cre)5Khn,
Tg(CMV-cre)1Cgn,
Tg(CMV-cre/ERT)1Ipc,
Tg(Col10a1-cre)1Xya,
Tg(Col1a1-cre)1Kry,
Tg(Col1a1-cre/ERT2)1Crm,
Tg(Col1a2-cre)23Angl,
Tg(Col1a2-cre/ERT,-ALPP)7Cpd,
Tg(COL2A1-cre)1Wag,
Tg(Col6a1-cre)1Gkl,
Tg(Cryaa-cre)10Mlr,
Tg(Cspg4-cre/Esr1*)BAkik,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp19a1-cre)5909Gle,
Tg(Cyp19a1-cre)5912Gle,
Tg(Cyp39a1-cre)1Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(dlx5a-cre)1Mekk,
Tg(EIIa-cre)C5379Lmgd,
Tg(Elf5-cre/ERT2,-GFP)2Rcha,
Tg(Eno2-cre)39Jme,
Tg(Fabp4-cre)1Abel,
Tg(Fabp4-cre)1Rev,
Tg(Fabp4-cre/ERT2)1Ipc,
Tgfb3tm1(cre)Vk,
Tg(Flt1-cre/ERT2)1Tmak,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(GH1-cre)1Sac,
Tg(Ghrhr-cre)3242Lsk,
Tg(Grem1-cre/ERT)3Tcw,
Tg(Grik4-cre)G32-4Stl,
Tg(Hoxa5-cre)444CLjea,
Tg(Hoxa5-cre)447BLjea,
Tg(Hoxb8-cre)1403Uze,
Tg(hs1163-Ccre,-lacZ)1Fawa,
Tg(Hspa2-cre)1Eddy,
Tg(I12b-cre)1Jlr,
Tg(Il7-cre)CRche,
Tg(Ins2-cre)25Mgn,
Tg(Islr-cre/ERT2)#Tobe,
Tg(Itgax-cre)1-1Reiz,
Tg(Klf4-cre/ERT)1Wai,
Tg(Krt10-cre/ERT)#Efu,
Tg(Krt1-15-cre/PGR*)22Cot,
Tg(KRT14-cre)1Amc,
Tg(KRT14-cre)1Cgn,
Tg(KRT14-cre)1Efu,
Tg(KRT14-cre)1Ipc,
Tg(KRT14-cre)43Smr,
Tg(KRT14-cre)8Brn,
Tg(KRT14-cre/ERT)20Efu,
Tg(KRT14-cre/ERT2)1Ipc,
Tg(KRT14-cre/PGR)1Der,
Tg(Krt1-5-cre/ERT)1Ipc,
Tg(Krt15-cre/ERT2)1Johu,
Tg(KRT18-cre/ERT2)1Rgo,
Tg(Krt2-6a-cre)1Ism,
Tg(KRT5-cre)5132Jlj,
Tg(KRT5-cre/ERT2)2Ipc,
Tg(KRT5-cre/ERT2)#Mym,
Tg(KRT5-cre/ERT)ICmch,
Tg(KRT5-cre/ERT)SCmch,
Tg(KRT5-cre/PGR)1Der,
Tg(Krt8-cre/ERT2,-GFP)1Xin,
Tg(LGB-cre)74Acl,
Tg(LTF-EGFP/cre/PGR)15Klin,
Tg(Lyve1-cre/ERT2)49Rtem,
Tgm3tm2(EGFP/cre/ERT2)Wtsi,
Tg(Mitf-cre)710-59Gsb,
Tg(Mitf-cre)7114Gsb,
Tg(MMTV-cre)105Ayn,
Tg(MMTV-cre)1Mam,
Tg(MMTV-cre)4Mam,
Tg(MMTV-cre)7Mul,
Tg(MMTV-cre)AElee,
Tg(MMTV-cre)BElee,
Tg(MMTV-cre)#Mam,
Tg(MMTV-flpo)11Gcr,
Tg(MMTV-flpo)29542Kuw,
Tg(MMTV-flpo)9Gcr,
Tg(Mpz-cre)94Imeg,
Tg(Mrgprb2-EGFP/cre)2Xzd,
Tg(Mrgprb2-EGFP/cre)3Xzd,
Tg(Mrgprb2-EGFP/cre)#Xzd,
Tg(Msx2-cre/ERT2)2Nono,
Tg(Mx1-cre)1Cgn,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Ntrk3-cre/ERT2)#Phep,
Tg(Pax3-cre)1Joe,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(PDPN-cre)#Rkl,
Tg(Pdzk1ip1-cre/ERT2)#Reiz,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx2-cre/Esr1*)#Hmd,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(Plp1-cre/ERT)3Pop,
Tg(Pou3f4-cre)32Cren,
Tg(Prdm1-cre)1Masu,
Tg(Prrx1-cre)1Cjt,
Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka,
Tg(Relb-cre)53Rie,
Tg(Retn-cre)1Laz,
Tg(Retnla-cre)#Voeh,
Tg(Rr437-cre)#Hmd,
Tg(rtetR-tetO-cre)40Mhz,
Tg(S100a4-cre)1Egn,
Tg(S100a4-cre)1Gle,
Tg(S100a4-flpo)3Lba,
Tg(S100b-cre)20Ito,
Tg(Scnn1a-cre)3Aibs,
Tg(Sim1-cre)1Lowl,
Tg(Stab2-icre)1.2Cger,
Tg(Tagln-cre)1Her,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)3Fech,
Tg(TCF/Lef1-cre/ERT2)#Ypc,
Tg(Tek-cre)1Ywa,
Tg(Tek-icre/ERT2)1Soff,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Tie1-cre)9Ref,
Tg(Tyr-cre)1Gfk,
Tg(Tyr-cre)1Lru,
Tg(Tyr-cre)2Lru,
Tg(Tyr-cre)3Gfk,
Tg(Tyr-cre/ERT2)13Bos,
Tg(Tyr-cre/ERT2)1Lru,
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde,
Tg(Tyr-cre)#Lru,
Tg(Ucp1-cre)1Evdr,
Tg(Ucp1-cre)#Brsp,
Tg(Wap-cre)11738Mam,
Tg(Wap-cre)1Gsc,
Tg(Wap-rtTA-cre)10Whl,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt7a-EGFP/cre)#Bhr,
Tg(WT1-cre)1Asc,
Tg(Zp3-cre)3Mrt,
Thtm1(cre)Te,
Tmprss2tm1.1(cre/ERT2)Ychen,
Trpv4em1(cre/ERT2)Amc,
Twist2tm1.1(cre)Dor,
Ucp1em1(cre)Chez,
Vimem1(cre/ERT2)Bzsh,
Wt1tm1(EGFP/cre)Wtp
(less)
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Recombinase Activity
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References
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Analysis Tools