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Tg(hs1006-cre/ERT2,-GFP)1Jlr - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(hs1006-cre/ERT2,-GFP)1Jlr
transgene insertion 1, John Rubenstein 		Driver: hs1006
Type: Transgenic (Inducible, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: 1006-CreER-IRES-GFP, Tg(WNT8B-cre/ERT2, GFP)1Jlr
Molecular description: This transgene contains the human enhancer element hs1006 -- which is flanked on human Chr 10 by the Wnt family member 8B (WNT8B) and SEC31 homolog B, COPII coat complex component (SEC31B) loci -- followed by a mouse minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(hs1006-cre/ERT2,-GFP)1Jlr activity also observed in:
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Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory