Sox2<tm1(cre/ERT2)Hoch> - Head Recombinase Activity Detail MGI Mouse

Sox2^{tm1(cre/ERT2)Hoch} - Head
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Sox2^{tm1(cre/ERT2)Hoch}
SRY (sex determining region Y)-box 2; targeted mutation 1, Konrad Hochedlinger

Driver: Sox2
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Sox2-Cre^ER

Molecular description:

A targeting construct encoding a cre recombinase/mutated estrogen ligand binding-domain (cre/ERT2) fusion sequence and an Frt-flanked neo cassette was targeted to the Sox2 locus in V6.5 ES cells, so that cre was under control of endogenous Sox2 regulatory elements. Chimeric mice were bred to 129/SvJae wild-type animals to test for germline transmission and to establish stable lines.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Sox2^{tm1(cre/ERT2)Hoch} activity also observed in:
sensory organs

Tissue Information

Head

Other recombinase alleles with activity in Head tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acan^{tm1(cre/ERT2)Crm}, Acsm4^tm1(cre)Hsak ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

108 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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