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Tg(S100b-EGFP/cre/ERT2)22Amc - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(S100b-EGFP/cre/ERT2)22Amc
transgene insertion 22, Andrew P McMahon 		Driver: S100b
Type: Transgenic (Inducible, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: S100b-GCE
Molecular description: A targeting construct containing the eGFPCreERT2 (GCE) cassette and FRT site flanked Kanamycin/neomycin selection cassette was inserted into the consensus start ATG codon of the gene in a BAC (RP23-213P2). The PGK-Neo/Kan cassette was removed by transient Flpe-recombinase expression. The resulting BAC transgene was microinjected into (C57BL/6 x DBA)F1 donor eggs. Founder line 22 was subsequently established. GFP fluorescence is not detectable by fluorescent microscope examination of whole embryos, bones or neural tube sagittal slices from embryos aged 15.5dpc. Tamoxifen induced cre recombinase activity is detected in a subset of the GFP immunoreactive-positive cells in bone.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(S100b-EGFP/cre/ERT2)22Amc activity also observed in:
limbs, mesenchyme, skeletal system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:159099 Fig. 3 S100b J:159099 Fig. 6 S100b J:159099 Fig. 8 S100b
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory