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Thtm1(cre/Esr1)Nat - Head
Recombinase Activity Detail
Allele Information
Allele:
Thtm1(cre/Esr1)Nat
tyrosine hydroxylase; targeted mutation 1, Jeremy Nathans 		Driver: Th
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: THCreER, THiCreER, TH-IRES-creER, TH-IRES-creER line C2, Thtm1(cre/ERT)Nat, Thtm1(cre/Esr1)Nat
Molecular description: An IRES-creER cassette, a tetracycline resistance gene, and an FRT-flanked neomycin selection marker were all knocked into the 3' UTR of the gene. The neomycin selection marker was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given tamoxifen, cre expression was detected in a sparse number of dopaminergic neurons in the brain. This is line C2.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Thtm1(cre/Esr1)Nat activity also observed in:
nervous system, sensory organs
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:155417 Fig. 5 J:155417 Fig. 6
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 16 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory