About   Help   FAQ
Foxp3tm4(YFP/icre)Ayr - Hemolymphoid System
Recombinase Activity Detail
Allele Information
Allele:
Foxp3tm4(YFP/icre)Ayr
forkhead box P3; targeted mutation 4, Alexander Y Rudensky 		Driver: Foxp3
Type: Targeted (Recombinase)
Synonym: Foxp3Cre, Foxp3tm4(YFP/cre)Ayr, Foxp3YFP-Cre
Molecular description: A YFP/icre fusion construct with an upstream IRES element and a downstream frt-flanked neomycin resistance cassette was placed into the downstream untranslated region of the gene. Chimeric mice were crossed with FLPe expressing mice to remove the neomycin selection cassette. YFP-cre expression based on YFP flouresecene was only detected in regulatory T cells. Crossing these mice with mice that contain a cre-mediated reporter gene also demonstrated low level cre expression in about 2-10% of hematopoietic lineage cells including immature and mature B cells, T cells, myeloid cells and bone marrow precursor cells.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Foxp3tm4(YFP/icre)Ayr activity also observed in:
mouse-other
Tissue Information
Hemolymphoid System Other recombinase alleles with activity in Hemolymphoid System tissues:
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 335 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory