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Lgr5tm1(cre/ERT2)Cle - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Lgr5tm1(cre/ERT2)Cle
leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Hans Clevers 		Driver: Lgr5
Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: Lgr5-cre, Lgr5CREER, Lgr5-creERT, Lgr5-CreERT2-IRES-EGFP, Lgr5-EGFP, Lgr5 EGFP-IRES-creERT2, Lgr5-EGFP-IRES-creERT2, Lgr5tm1(cre/ESR1)Cle, Lgr5UT
Molecular description: An EGFP-IRES-creERT2 cassette was inserted into exon 1 of the gene along with a loxP-flanked neomycin cassette. The neomycin gene was then excised in vivo by crossing with cre-deleter strain. GFP expression is driven by the endogenous promoter. Cre expression is induced in Lgr5 expressing cells by tamoxifen treatment.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Lgr5tm1(cre/ERT2)Cle activity also observed in:
alimentary system, integumental system, reproductive system
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Images
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J:328554 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 533 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory