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Tg(Slc5a2-cre)1Tauc - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Slc5a2-cre)1Tauc
transgene insertion 1, Michel Tauc 		Driver: Slc5a2
Type: Transgenic (Recombinase)
Synonym: iL1-sglt2-Cre, mSglt2 5pr-mut-Cre
Molecular description: The transgene expresses Cre recombinase under control of the promoter region of the gene encoding solute carrier family 5 (sodium/glucose cotransporter), member 2, including 1952 bp of 5'-flanking sequence, the first exon (containing a mutated translation initiation codon), first intron and 23 bp of the second exon. X-gal staining of multiple tissues from mice doubly transgenic for this transgene and for the E. coli beta-galactosidase gene (lacZ) preceded by a loxP-flanked stop sequence (knocked into the Gt(ROSA)26Sor locus) demonstrated beta-galactosidase activity only in the kidney. Immunohistochemical analysis of X-gal-stained kidney cryostat sections for markers specific to different regions of the nephron showed colocalization of X-gal staining only with anti-megalin antibody, which identifies the proximal tubules.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 20 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory