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Tg(Krt1-15-cre/PGR*)22Cot - Integumental System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Krt1-15-cre/PGR*)22Cot
transgene insertion 22, George Cotsarelis 		Driver: Krt15
Type: Transgenic (Inducible, Recombinase)
Inducer: mifepristone
Synonym: K15CrePR, K15-CrePR1, Krt15-cre/PGR)22Cot, Tg(Krt1-15-cre/PGR)22Cot
Molecular description: The transgene comprises the entire 5.0-kb mouse Krt1-15 promoter region driving expression of a fusion protein composed of an amino-terminal nuclear localization signal followed by Cre recombinase joined to the carboxyl-terminal hormone-binding domain (HBD) of a mutant human progesterone receptor. This mutant HBD, whose carboxyl-terminal is truncated by 42 amino acids, fails to bind endogenous progestins but binds and, paradoxically, is activated by progesterone receptor antagonists such as RU486. Constitutive expression of the fusion protein is directed by the Krt1-15 promoter to epithelial stem cells in the bulge region of the hair follicle. It remains inactive in the cytoplasm until bound to RU486, whereupon it translocates to the nucleus and can catalyze loxP-mediated recombination.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Krt1-15-cre/PGR*)22Cot activity also observed in:
alimentary system
Tissue Information
Integumental System Other recombinase alleles with activity in Integumental System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 71 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory