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Tg(Ins2-cre)25Mgn - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Ins2-cre)25Mgn
transgene insertion 25, Mark A Magnuson
Driver: Ins2
Type: Transgenic (Recombinase)
Synonym: Ins2cre, Ins-Cre, M line, RIP2-cre, RIP2Cre, Rip-cre, RIPCre, [RIP]-Cre, RIP Cre, RIP-Cre, TgN(ins2-Cre)25Mgn
Molecular description: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of the rat insulin promoter (Ins2), which is active in pancreatic beta cells and in neurons of the hypothalamus. 9 copies of the transgene are estimated to be present. Transgene insertion occurred on Chr 7, causing a 17400 bp duplication.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Ins2-cre)25Mgn activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:166612 Fig. 1 J:193672 Full image
Fig. Ins2 Brain P56
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Fig. Ins2 Brain P7
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Fig. Ins2 Embryo 1 E10.5
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Fig. Ins2 Embryo 2 E10.5
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Fig. Ins2 Embryo 2 E15.5
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Fig. Ins2 Embryo 3 E10.5
J:193672 Fig. Ins2 Embryo 3 E15.5
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Fig. Ins2 Embryo 4 E10.5
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Fig. Ins2 Eye P56
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Fig. Ins2 Opt Nerve P7
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Fig. Ins2 Sp Cord (cerv) P56
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Fig. Ins2 Sp Cord (cerv) P7
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Fig. Ins2 Sp Cord (lumbar) P56
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Fig. Ins2 Sp Cord (lumbar) P7
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Fig. Ins2 Sp Cord (thorac) P56
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Fig. Ins2 Sp Cord (thorac) P7
J:69314 Fig. 1 J:69314 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 286 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory