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Tg(Nes-cre)1Kln - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nes-cre)1Kln
transgene insertion 1, Rudiger Klein 		Driver: Nes
Type: Transgenic (Recombinase)
Synonym: n-Cre+, Nes11Cre, NesCre, nestin-Cre, nestin/Cre, Nestin:Cre, Tg(Nes-cre), Tg(Nest-cre)1Jln, TgN(NesCre)1Kln
Molecular description: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of a rat nestin (Nes) promoter and the nervous system-specific enhancer present in the second intron. This promoter expresses Cre recombinase in neuronal and glial cell precursors. Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene was localized to chromosome 12 using FISH with a rat nestin promoter probe (J:180046). The insertion caused a 17 bp deletion.
Find mice (IMSR): Mouse Strains: 4 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Nes-cre)1Kln activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:102190 Fig. 1 J:102190 Fig. S2 J:108509 Fig. S2 J:137251 Fig. 2 J:137251 Fig. 4 J:137251 Fig. 6 J:137251 Fig. S2 J:137251 Fig. S3
J:184578 Full Image
Fig. Nes Brain P56 J:184578 Full Image
Fig. Nes Brain P7 J:184578 Full Image
Fig. Nes Embryo 2 E10.5 J:184578 Full Image
Fig. Nes Embryo 2 E15.5 J:184578 Full Image
Fig. Nes Embryo E10.5 J:184578 Full Image
Fig. Nes Embryo E15.5 J:96910 Fig. 2 J:99607 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1347 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory