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V-beta-8 Probe Detail
Nucleotide
Probe/Clone
  • Name
    V-beta-8
  • Sequence Type
    genomic
  • ID
    MGI:9534
  • Region Covered
    S18.4 V beta region covering amino acid 13-95
  • Insert Size
    246bp
Source
  • Species
    mouse, laboratory
  • Tissue
    helper T-lymphocyte
  • Cell Line
    S18.4
Genes
Trbv12-2 T cell receptor beta, variable 12-2
Tcrb-V8 T cell receptor beta, variable 8
Polymorphisms
J:7927 Sim GK, et al., Cell. 1985 Aug;42(1):89-92
Endonuclease Gene Allele Fragments Strains
EcoRI Trbv12-2 - absent C57BR, SJL/J, SWR/J
+ 4.2,5.0kb AKR, B10.A-H2a, BALB/c, C57BL/6
HindIII Trbv12-2 - absent C57BR, SJL/J, SWR/J
+ 9.5,1.0kb AKR, B10.A-H2a, BALB/c, C57BL/6
J:10143 Nobuhara H, et al., Immunogenetics. 1989;30(6):405-13
Notes: Additional unique RFLP alleles were observed among wild strains and Mus subspecies.
Endonuclease Gene Allele Fragments Strains
EcoRI Tcrb-V8 a 4.8,3.5,0.8kb A/J, AKR/J, BALB/cAnN, C3H/HeJ, C57BL/6J, C57BL/10J, C58/J, CBA/J, DBA/1J, DBA/2J, I/LnJ, LP.RIIIS-H2r/J, MA/MyJ, NZB/BlNJ, P/J, PL/J, RBF/DnJ, SL/Qdj, SM/J
b V[b]8 family deleted AU/SsJ, C57L/J, RIIIS/J, SJL/J
J:10641 Vidard L, et al., Immunogenetics. 1990;32(1):27-33
Endonuclease Gene Allele Fragments Strains
EcoRI Tcrb-V8 a 4.8,3.5,0.8kb ABH, ABL, BALB/c
b - (deleted) SJL/J
References
J:7927 Sim GK, et al., V beta gene polymorphism and a major polyclonal T cell receptor idiotype. Cell. 1985 Aug;42(1):89-92
J:10143 Nobuhara H, et al., Polymorphism of T-cell receptor genes among laboratory and wild mice: diverse origins of laboratory mice. Immunogenetics. 1989;30(6):405-13
J:10641 Vidard L, et al., Polymorphism of Tcrb and Tcrg genes in Biozzi mice: segregation analysis of a new Tcrg haplotype with antibody responsiveness. Immunogenetics. 1990;32(1):27-33
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory