5'CDR2 probe Probe Detail MGI Mouse MGI:9234

5'CDR2 probe Probe Detail

Name

5'CDR2 probe
Sequence Type

Not Specified
ID

MGI:9234
Region Covered

hybridizes to complementarity determining region 2 of the Igh-VJ558 H241/102 gene segment
Insert Size

23.0bp

Species

Not Specified

immunoglobulin heavy chain (J558 family)

J:15216 Gangemi RM, et al., J Immunol. 1993 Nov 1;151(9):4660-71

Notes: The band observed using SWR DNA (XbaI digest) is much less intense than bands originating from the other strains. The authors suggest diminished homology between probe and restriction fragment as a cause.

Endonuclease	Gene	Allele	Fragments	Strains
EcoRI	Igh-VJ558	a	5.8kb	BALB/c
		j	16.0kb	C3H, MRL, NZB
		p	5.3kb	DBA/2
XbaI	Igh-VJ558	c	6.0kb	DBA/2
		j	6.2kb	BALB/c, C3H, MRL, NZB, NZW
		p	5.7kb	SWR

J:15216 Gangemi RM, et al., Independently derived IgG anti-DNA autoantibodies from two lupus-prone mouse strains express a VH gene that is not present in most murine strains. J Immunol. 1993 Nov 1;151(9):4660-71

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