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Otx2 cDNA1 Probe Detail
Nucleotide
Probe/Clone
  • Name
    Otx2 cDNA1
  • Sequence Type
    cDNA
  • ID
    MGI:1331375
  • Vector Type
    Plasmid
  • Insert Site
    HaeIII
  • Insert Size
    0.263kb
Source
  • Species
    mouse, laboratory
Genes
Otx2 orthodenticle homeobox 2
Expression
  • Assay Results
    173
References
J:24127 Simeone A, et al., A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 1993 Jul;12(7):2735-47
J:19476 Simeone A, et al., Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila. Neuron. 1994 Jul;13(1):83-101
J:29276 Acampora D, et al., Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90
J:36832 Stoykova A, et al., Forebrain patterning defects in Small eye mutant mice. Development. 1996 Nov;122(11):3453-65
J:42110 Wassarman KM, et al., Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development. 1997 Aug;124(15):2923-34
J:52989 Acampora D, et al., Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes. Development. 1999 Apr;126(7):1417-26
J:53903 Theil T, et al., Gli3 is required for Emx gene expression during dorsal telencephalon development. Development. 1999 Aug;126(16):3561-71
J:55154 Schwarz M, et al., Pax2/5 and Pax6 subdivide the early neural tube into three domains. Mech Dev. 1999 Apr;82(1-2):29-39
J:58078 Liu A, et al., FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development. 1999 Nov;126(21):4827-38
J:66592 Liu A, et al., EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Development. 2001 Jan;128(2):181-91
J:68215 Xue Y, et al., Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK). Development. 2001 May;128(9):1559-72
J:69855 Martinez-Morales JR, et al., Otx genes are required for tissue specification in the developing eye. Development. 2001 Jun;128(11):2019-30
J:83255 Chi CL, et al., The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development. 2003 Jun;130(12):2633-44
J:98077 Alfano G, et al., Natural antisense transcripts associated with genes involved in eye development. Hum Mol Genet. 2005 Apr 1;14(7):913-23
J:108393 Chung AC, et al., Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer. Dev Biol. 2006 May 1;293(1):13-24
J:135242 Kala K, et al., Analysis of the midbrain-hindbrain boundary cell fate using a boundary cell-specific Cre-mouse strain. Genesis. 2008 Jan;46(1):29-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory