p-alpha-(J558)13
Probe Detail
-
Name
p-alpha-(J558)13
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Sequence Type
cDNA
-
ID
MGI:12706
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Region Covered
encodes a small 3'-portion of the Igh-VJ558 gene segment J558, Igh-D, Igh-J gene segments and most of the Igh-2 gene segment (C1, C2, most of C3)
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Vector Type
Plasmid
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Insert Site
EcoRI
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Insert Size
~1150bp
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Synonyms
pJ558
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Species
mouse, laboratory
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Strain
BALB/c
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Tissue
myeloblast
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Cell Line
myeloma cell line J558
|
Igha
|
immunoglobulin heavy constant alpha
|
|
|
Igh-D
|
immunoglobulin heavy chain diversity region
|
|
|
Igh-J
|
immunoglobulin heavy chain, joining region
|
|
|
Igh-VJ558
|
immunoglobulin heavy chain (J558 family)
|
|
J:6394
Marcu KB, et al., Cell. 1980 Nov;22(1 Pt 1):187-96
| Endonuclease |
Gene |
Allele |
Fragments |
Strains |
| EcoRI |
Igha |
a |
10.0,6.6,4.5kb |
BALB/c, C3H/HeJ, C57L/J |
| b |
9.4,4.5kb |
C57BL/6J, SM/J |
| n |
10.0,6.6,4.5kb |
NZB |
| HindIII |
Igha |
a |
5.2kb |
BALB/c, C3H/HeJ, C57L/J |
| b |
4.8kb |
C57BL/6J, SM/J |
| n |
5.6kb |
NZB |
| KpnI |
Igha |
a |
10.5kb |
BALB/c, C3H/HeJ, C57L/J |
| b |
9.8kb |
C57BL/6J, SM/J |
| n |
10.6kb |
NZB |
J:6394
Marcu KB, et al., 5' flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains. Cell. 1980 Nov;22(1 Pt 1):187-96
J:6722
Tucker PW, et al., Mouse IgA heavy chain gene sequence: implications for evolution of immunoglobulin hinge axons. Proc Natl Acad Sci U S A. 1981 Dec;78(12):7684-8
J:8641
Brown EH, et al., Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon. Mol Cell Biol. 1987 Jan;7(1):450-7
J:9308
Osborne BA, et al., Evolution of the IgA heavy chain gene in the genus Mus. Genetics. 1988 Aug;119(4):925-31
Analysis Tools