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pMHC101 Probe Detail
Nucleotide
Probe/Clone
  • Name
    pMHC101
  • Sequence Type
    cDNA
  • ID
    MGI:11977
  • Region Covered
    5'-portion of the cDNA
  • Vector Type
    Plasmid
  • Insert Site
    PstI
  • Insert Size
    ~0.6 kb
Source
  • Species
    mouse, laboratory
  • Age
    embryonic day 12.0
  • Tissue
    heart
Genes
Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha
Sequences
M12290 (GenBank | EMBL | ENA | DDBJ | MGI Sequence Detail)
Polymorphisms
J:8079 Weydert A, et al., Proc Natl Acad Sci U S A. 1985 Nov;82(21):7183-7
Endonuclease Gene Allele Fragments Strains
BclI Myh6 d 5.8kb DBA/2
s 10kb M. spretus
J:10182 Beisel KW, et al., Nucleic Acids Res. 1989 Dec 25;17(24):10519
Notes: The endonucleases that failed to show RFLP's were tested only with A/J vs. C57BL/6J strains.
Endonuclease Gene Allele Fragments Strains
BglII Myh6 a 4.2,2.4,1.9kb 129P3/J, A/J, BALB/cJ, BUB/BnJ, C3H/HeJ, CBA/J, CE/J, I/LnJ, NZB/BlNJ, P/J, RF/J, RIIIS/J, ST/bJ, YBR/EiJ
b 9.0,2.4,1.2kb C57BL/6J, C57BL/10J, C57L/J
c 3.8,2.4,1.9kb DBA/2J, PL/J, SJL/J, SWR/J
J:2596 Haefliger JA, et al., J Biol Chem. 1992 Jan 25;267(3):2057-64
Endonuclease Gene Allele Fragments Strains
SpnI Myh6 b ~23,12.0,8.2,7.4,3.1kb C57BL/6J
s ~23,12.5,8.2,7.0,5.8,3.1,2.9kb M. spretus
References
J:8079 Weydert A, et al., Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7183-7
J:10182 Beisel KW, et al., Identification of three alleles for Mus musculus at the Myhc-a locus which co-segregates with Np-2, Tcra and Rib-1 on chromosome 14. Nucleic Acids Res. 1989 Dec 25;17(24):10519
J:2596 Haefliger JA, et al., Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. J Biol Chem. 1992 Jan 25;267(3):2057-64
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory