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pP3450FL Probe Detail
Nucleotide
Probe/Clone
  • Name
    pP3450FL
  • Sequence Type
    cDNA
  • ID
    MGI:11921
  • Region Covered
    full length cDNA
  • Vector Type
    Plasmid
  • Insert Site
    BamHI
  • Insert Size
    ~1.9kb
  • Note
    Insert was subcloned from the vector pCD.
  • Synonyms
    P3450FL
Source
  • Species
    mouse, laboratory
  • Strain
    C57BL/6N
  • Tissue
    liver
Genes
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2
Sequences
Polymorphisms
J:7969 Hildebrand CE, et al., Biochem Biophys Res Commun. 1985 Jul 16;130(1):396-406
Endonuclease Gene Allele Fragments Strains
PvuII Cyp1a2 a 4.6kb AKR/J
b 4.8kb C57BL/6J, C57L/J, DBA/2J
J:8783 Prochazka M, et al., Science. 1987 Jul 17;237(4812):286-9
Endonuclease Gene Allele Fragments Strains
PvuII Cyp1a2 a 4.6kb NON/ShiLt
b 4.8kb NOD/ShiLt
J:10074 Kingsley DM, et al., Genetics. 1989 Sep;123(1):165-72
Notes: A BamHI/HindIII subclone from the 3' end was used as a probe for Southern analysis. Additional weakly hybridizing bands were observed.
Endonuclease Gene Allele Fragments Strains
EcoRI Cyp1a2 b 10.5kb C57BL/6J
s 14.4kb M. spretus
J:29464 Prochazka M, et al., Diabetes. 1989 Nov;38(11):1446-55
Endonuclease Gene Allele Fragments Strains
HindIII Cyp1a2 d ~5.0kb NOD/ShiLt
n ~5.5,~5.0kb NON/ShiLt
References
J:7553 Kimura S, et al., The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. J Biol Chem. 1984 Sep 10;259(17):10705-13
J:7616 Gonzalez FJ, et al., Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450. Gene. 1984 Sep;29(3):281-92
J:7969 Hildebrand CE, et al., Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9. Biochem Biophys Res Commun. 1985 Jul 16;130(1):396-406
J:8783 Prochazka M, et al., Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice [published erratum appears in Science 1988 Nov 11;242(4880):945]. Science. 1987 Jul 17;237(4812):286-9
J:10074 Kingsley DM, et al., A molecular genetic linkage map of mouse chromosome 9 with regional localizations for the Gsta, T3g, Ets-1 and Ldlr loci. Genetics. 1989 Sep;123(1):165-72
J:29464 Prochazka M, et al., Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocks. Diabetes. 1989 Nov;38(11):1446-55
J:29147 Nebert DW, Personal Communication. Personal Communication. 1990;

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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory