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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Scn5a
sodium channel, voltage-gated, type V, alpha
MGI:98251
49 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Scn5aem1Coop/Scn5a+
involves: FVB/NJ 		abnormal impulse conducting system conduction J:279087
abnormal QT interval J:279087
abnormal sinoatrial node conduction J:279087
atrioventricular block J:279087
irregular heartbeat J:279087
prolonged QRS complex duration J:279087
Scn5aem1Coop/Scn5aem1Coop
involves: C57BL/6NJ * FVB/NJ 		abnormal heart electrocardiography waveform feature J:279087
Scn5aem1Coop/Scn5aem1Coop
involves: FVB/NJ 		abnormal heart electrocardiography waveform feature J:279087
abnormal impulse conducting system conduction J:279087
abnormal QT interval J:279087
abnormal sinoatrial node conduction J:279087
atrioventricular block J:279087
decreased heart rate J:279087
irregular heartbeat J:279087
prolonged PR interval J:279087
prolonged QRS complex duration J:279087
sinus bradycardia J:279087
ventricular tachycardia J:279087
Scn5atm1.1Iba/Scn5a+
involves: 129 * C57BL/6 		abnormal action potential J:266290
abnormal heart atrium morphology J:266290
abnormal heart echocardiography feature J:266290
abnormal heart morphology J:266290
abnormal myocardial fiber physiology J:266290
abnormal myocardial fiber sodium currents J:266290
atrioventricular block J:266290
cardiac fibrosis J:266290
congestive heart failure J:266290
decreased body weight J:266290
increased heart weight J:266290
increased lung weight J:266290
increased myocardial fiber size J:266290
irregular heartbeat J:266290
liver vascular congestion J:266290
premature death J:266290
prolonged QRS complex duration J:266290
prolonged QT interval J:266290
thick ventricular wall J:266290
ventricular fibrillation J:266290
ventricular premature beat J:266290
ventricular tachycardia J:266290
Scn5atm1Agrc/Scn5a+
involves: 129 		abnormal impulse conducting system conduction J:109689
cardiac fibrosis J:109689
decreased heart rate J:109689
prolonged P wave J:109689
prolonged PR interval J:109689
prolonged QRS complex duration J:109689
prolonged QT interval J:109689
ventricular tachycardia J:166438
Scn5atm1Agrc/Scn5a+
involves: 129 * C57BL/6J 		abnormal heart rate J:76331
abnormal impulse conducting system conduction J:76331
abnormal myocardial fiber physiology J:76331
prolonged P wave J:76331
prolonged PR interval J:76331
ventricular tachycardia J:76331
Scn5atm1Agrc/Scn5atm1Agrc
involves: 129 * C57BL/6J 		abnormal cardiac muscle contractility J:76331
abnormal heart ventricle morphology J:76331
abnormal trabecula carnea morphology J:76331
decreased embryo size J:76331
decreased myocardial fiber number J:76331
embryonic lethality during organogenesis, complete penetrance J:76331
Scn5atm1Care/Scn5a+
FVB.129P2-Scn5atm1Care/Care 		abnormal impulse conducting system conduction J:128657
abnormal myocardial fiber physiology J:128657
abnormal sinoatrial node conduction J:128657
decreased heart rate J:128657
normal mortality/aging J:128657
prolonged PQ interval J:128657
prolonged QRS complex duration J:128657
prolonged QT interval J:128657
Scn5atm1Care/Scn5atm1Care
FVB.129P2-Scn5atm1Care/Care 		prenatal lethality, complete penetrance J:128657
Scn5atm1Clhh/Scn5a+
involves: 129 * 129S/SvEv * C57BL/6J 		abnormal impulse conducting system conduction J:127879
abnormal myocardial fiber physiology J:127879
increased susceptibility to induced morbidity/mortality J:127879
irregular heartbeat J:127879
postnatal lethality, incomplete penetrance J:127879
seizures J:127879
ventricular tachycardia J:127879
Scn5atm1Clhh/Scn5a+
involves: 129/SvEv 		abnormal atrioventricular node conduction J:186583
abnormal impulse conducting system conduction J:186583
abnormal sinoatrial node conduction J:186583
atrioventricular block J:186583
prolonged PR interval J:186583
prolonged QRS complex duration J:186583
prolonged QT interval J:186583
sinus bradycardia J:186583
Scn5atm1Clhh/Scn5atm1Clhh
involves: 129 * 129S/SvEv * C57BL/6J 		decreased embryo size J:127879
embryo tissue necrosis J:127879
irregular heartbeat J:127879
prenatal lethality, complete penetrance J:127879
Scn5atm1Pec/Scn5a+
involves: Swiss 		abnormal impulse conducting system conduction J:71542
abnormal T wave J:71542
decreased heart rate J:71542
irregular heartbeat J:71542
premature death J:71542
prolonged QT interval J:71542
Scn5atm1Pec/Scn5atm1Pec
involves: Swiss 		abnormal cardiovascular system physiology J:71542
embryonic lethality during organogenesis, complete penetrance J:71542
Scn5atm2.1Care/Scn5atm2.1Care
B6J.129P2(Cg)-Scn5atm2.1Care 		abnormal atrioventricular bundle conduction J:224433
abnormal impulse conducting system conduction J:224433
abnormal myocardial fiber physiology J:224433
normal cardiovascular system phenotype J:224433
normal mortality/aging J:224433
prolonged P wave J:224433
prolonged PR interval J:224433
prolonged QRS complex duration J:224433
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory