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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Scn1a
sodium channel, voltage-gated, type I, alpha
MGI:98246
9 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Kcnq2Nmf134/\Kcnq2+
\Scn1atm1.1Aesc/\Scn1a+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J 		convulsive seizures J:170734
decreased survivor rate J:170734
postnatal lethality, incomplete penetrance J:170734
tonic-clonic seizures J:170734
\Scn1atm1.1Aesc/\Scn1a+
\Scn8amed-jo/\Scn8a+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * DBA/2WyDi 		normal behavior/neurological phenotype J:170734
\Scn1atm1.1Aesc/\Scn1a+
\Tg(Eno2-Scn2a1*)Q54Mm/0
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * SJL/J 		convulsive seizures J:170734
postnatal lethality, complete penetrance J:170734
tonic-clonic seizures J:170734
\Scn1atm1.1Aesc/\Scn1atm1.1Aesc
\Scn8amed-jo/\Scn8a+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * DBA/2WyDi 		decreased survivor rate J:170734
postnatal lethality, incomplete penetrance J:170734
\Scn1atm1Wac/\Scn1a+
\Scn8amed-jo/\Scn8a+
involves: 129 * C57BL/6J * DBA/2WyDi * FVB/NJ 		abnormal spike wave discharge J:129998
normal mortality/aging J:129998
normal nervous system phenotype J:129998
\Scn1atm1Wac/\Scn1atm1Wac
\Scn8amed-jo/\Scn8a+
involves: 129 * C57BL/6J * DBA/2WyDi * FVB/NJ 		postnatal lethality, complete penetrance J:129998
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory