Gja5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gja5
gap junction protein, alpha 5
MGI:95716

31 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gja5^tm1Kwi/Gja5^tm1Kwi involves: 129S4/SvJae * C57BL/6	abnormal impulse conducting system conduction	J:46429
	increased heart rate	J:46429
	irregular heartbeat	J:46429
	prolonged P wave	J:46429
	prolonged PQ interval	J:46429
	prolonged QRS complex duration	J:46429
	prolonged QT interval	J:46429
Gja5^tm1Mchn/Gja5^tm1Mchn involves: BALB/c * C57BL/6	no abnormal phenotype detected	J:162224
Gja5^tm1Mchn/Gja5^tm1Mchn Tg(Tek-cre/ERT2)1Arnd/0 involves: C57BL/6 * DBA/2	increased susceptibility to injury	J:161949
Gja5^tm1Paul/Gja5⁺ involves: 129S4/SvJae * C57BL/6	abnormal aortic arch and aortic arch branch attachment	J:109301
	abnormal heart morphology	J:109301
	bifid atrial appendage	J:109301
	ventricular septal defect	J:109301
Gja5^tm1Paul/Gja5^tm1Paul either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)	abnormal frontal plane axis	J:46430
	abnormal impulse conducting system conduction	J:46430
	abnormal QRS complex	J:46430
	bundle branch block	J:46430
	fragmented QRS complex	J:46430
	prolonged P wave	J:46430
	prolonged PR interval	J:46430
	prolonged QRS complex duration	J:46430
	prolonged QT interval	J:46430
Gja5^tm1Paul/Gja5^tm1Paul involves: 129S4/SvJae	increased susceptibility to injury	J:161949
Gja5^tm1Paul/Gja5^tm1Paul involves: 129S4/SvJae * C57BL/6	abnormal atrioventricular cushion morphology	J:109301
	abnormal heart morphology	J:109301
	common atrioventricular valve	J:109301
	dilated cardiomyopathy	J:109301
	double outlet right ventricle	J:109301
	mitral valve stenosis	J:109301
	neonatal lethality, incomplete penetrance	J:109301
	ostium primum atrial septal defect	J:109301
	pulmonary artery hypoplasia	J:109301
Gja5^tm2.1Kwi/Gja5^tm2.1Kwi involves: 129P2/OlaHsd * C57BL/6 * SJL	decreased mean systemic arterial blood pressure	J:205109
	increased circulating renin level	J:205109
Tg(Tie2-Gja5*,-EGFP)#Dach/0 involves: C57BL/6	abnormal blood vessel morphology	J:218811
	normal cardiovascular system phenotype	J:218811
	normal growth/size/body region phenotype	J:218811
Tg(Tie2-Gja5,-EGFP)#Dach/0 involves: C57BL/6	abnormal blood vessel morphology	J:218811
	normal cardiovascular system phenotype	J:218811
	normal growth/size/body region phenotype	J:218811

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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