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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Col8a2
collagen, type VIII, alpha 2
MGI:88464
14 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Col8a2Aca23/Col8a2+
C57BL/6J-Col8a2Aca23 		abnormal cornea epithelium morphology J:158259
abnormal eye anterior chamber morphology J:158259
abnormal eye morphology J:158259
decreased cornea stroma thickness J:158259
decreased cornea thickness J:158259
decreased Descemet membrane thickness J:158259
enlarged eye anterior chamber J:158259
normal vision/eye phenotype J:158259
Col8a2Aca23/Col8a2Aca23
C57BL/6J-Col8a2Aca23 		abnormal cornea epithelium morphology J:158259
abnormal eye anterior chamber morphology J:158259
abnormal eye morphology J:158259
decreased cornea stroma thickness J:158259
decreased cornea thickness J:158259
decreased Descemet membrane thickness J:158259
enlarged eye anterior chamber J:158259
normal vision/eye phenotype J:158259
Col8a2tm1.1Asj/Col8a2tm1.1Asj
involves: 129S6/SvEvTac 		abnormal autophagy J:214908
abnormal cornea endothelium morphology J:214908
abnormal Descemet membrane morphology J:214908
abnormal endoplasmic reticulum morphology J:214908
Col8a2tm1.1Asj/Col8a2tm1.1Asj
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal cornea endothelium morphology J:179022
abnormal Descemet membrane morphology J:179022
abnormal endoplasmic reticulum morphology J:179022
abnormal mitochondrial morphology J:179022
increased apoptosis J:179022
Col8a2tm1Bjro/Col8a2tm1Bjro
B6.129S4-Col8a2tm1Bjro 		abnormal Descemet membrane morphology J:100136
decreased Descemet membrane thickness J:100136
Col8a2tm2.1Asj/Col8a2tm2.1Asj
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal autophagy J:214908
abnormal cornea endothelium morphology J:214908
abnormal Descemet membrane morphology J:214908
abnormal endoplasmic reticulum morphology J:214908
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory