163 phenotypes from 15 alleles in 17 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Col2a1Dmm/Col2a1+ involves: 101 * C3H	abnormal long bone epiphysis morphology	J:6582
	abnormal postnatal growth/weight/body size	J:6582
	disproportionate dwarf	J:6582
	postnatal lethality, incomplete penetrance	J:6582
	short limbs	J:6582
	shortened head	J:6582
Col2a1Dmm/Col2a1Dmm involves: 101 * C3H	abnormal chondrocyte morphology	J:6582, J:37522
	abnormal long bone epiphysis morphology	J:6582
	abnormal lung volume	J:17182
	abnormal neurocranium morphology	J:6582
	abnormal pulmonary alveolus morphology	J:17182
	cleft palate	J:6582
	decreased length of long bones	J:6582
	disproportionate dwarf	J:6582
	perinatal lethality, complete penetrance	J:17182
	prenatal lethality, incomplete penetrance	J:6582
	pulmonary hypoplasia	J:17182
	respiratory distress	J:17182
	short limbs	J:6582, J:37522
	short mandible	J:6582
	short ribs	J:17182
	short vertebral column	J:37522
	small thoracic cage	J:37522
Col2a1Lpk/Col2a1+ C.B6(C3)-Col2a1Lpk	abnormal skeleton morphology	J:187141
Col2a1Lpk/Col2a1+ either: C3H.Cg-Col2a1Lpk/H or (involves: C3H/HeH * C57BL/6J)	short limbs	J:148829
Col2a1Lpk/Col2a1+ involves: C3H/HeH * C57BL/6J	abnormal bone ossification	J:187141
	abnormal bone structure	J:187141
	abnormal cartilage development	J:187141
	abnormal cartilage morphology	J:187141
	abnormal chondrocyte morphology	J:187141
	abnormal elbow joint morphology	J:187141
	abnormal epiphyseal plate morphology	J:187141
	abnormal joint mobility	J:187141
	abnormal limb long bone morphology	J:187141
	abnormal long bone epiphyseal ossification zone morphology	J:187141
	abnormal long bone epiphysis morphology	J:187141
	abnormal long bone metaphysis morphology	J:187141
	abnormal skeleton development	J:187141
	abnormal skeleton physiology	J:187141
	abnormal trabecular bone morphology	J:187141
	abnormal ulna morphology	J:187141
	decreased body weight	J:187141
	decreased bone mineral density	J:187141
	decreased bone trabecula number	J:187141
	decreased bone volume	J:187141
	decreased trabecular bone volume	J:187141
	decreased width of hypertrophic chondrocyte zone	J:187141
	delayed endochondral bone ossification	J:187141
	disorganized long bone epiphyseal plate	J:187141
	increased compact bone thickness	J:187141
	short femur	J:187141
	short humerus	J:187141
	short lumbar vertebrae	J:187141
	short snout	J:187141
	short tibia	J:187141
	short ulna	J:187141
Col2a1Lpk/Col2a1Lpk involves: C3H/HeH * C57BL/6J	abnormal cartilage development	J:187141
	abnormal cartilage morphology	J:187141
	abnormal chondrocyte morphology	J:187141
	abnormal long bone epiphyseal plate proliferative zone	J:187141
	cleft palate	J:187141
	decreased fetal size	J:187141
	decreased length of long bones	J:187141
	disorganized long bone epiphyseal plate	J:187141
	increased diameter of long bones	J:187141
	perinatal lethality, complete penetrance	J:187141
Col2a1m1Btlr/Col2a1+ C57BL/6J-Col2a1m1Btlr/Btlr	short femur	J:309727
	short tibia	J:309727
Col2a1m1Btlr/Col2a1m1Btlr C57BL/6J-Col2a1m1Btlr/Btlr	short femur	J:309727
	short tibia	J:309727
Col2a1M2J/Col2a1+ B6;C3Fe-Col2a1M2J/GrsrJ	cleft palate	J:176116, J:187363
	decreased percent body fat/body weight	J:187363
	increased body weight	J:187363
	increased cranium length	J:187363
	increased percent body fat/body weight	J:187363
	short snout	J:187363
Col2a1M3J/Col2a1+ B6(Cg)-Col2a1M3J/GrsrJ	short snout	J:206718
Col2a1mc13/Col2a1mc13 involves: C57BL/6J * FVB/NJ	abnormal head shape	J:225386
	abnormal limb long bone morphology	J:225386
	abnormal limb morphology	J:225386
	decreased length of long bones	J:225386
	increased diameter of femur	J:225386
	increased diameter of fibula	J:225386
	increased diameter of humerus	J:225386
	increased diameter of long bones	J:225386
	increased diameter of radius	J:225386
	increased diameter of tibia	J:225386
	increased diameter of ulna	J:225386
	microcephaly	J:225386
	short femur	J:225386
	short fibula	J:225386
	short humerus	J:225386
	short limbs	J:225386
	short mandible	J:225386
	short radius	J:225386
	short tibia	J:225386
	short ulna	J:225386
Col2a1Rgsc413/Col2a1+ involves: C57BL/6JJcl * DBA/2JJcl	abnormal long bone epiphyseal plate proliferative zone	J:260538
	disorganized long bone epiphyseal plate	J:260538
	short forelimb	J:133634
Col2a1Rgsc413/Col2a1Rgsc413 involves: C57BL/6JJcl * DBA/2JJcl	abnormal long bone epiphyseal plate proliferative zone	J:260538
	abnormal pelvic girdle bone morphology	J:260538
	decreased body size	J:260538
	disorganized long bone epiphyseal plate	J:260538
	increased chondrocyte apoptosis	J:260538
	perinatal lethality, complete penetrance	J:260538
	platyspondylia	J:260538
	short limbs	J:260538
	short snout	J:260538
Col2a1Rgsc856/Col2a1+ involves: C57BL/6JJcl * DBA/2JJcl	abnormal chondrocyte morphology	J:171906
	abnormal chondrocyte physiology	J:171906
	abnormal epiphyseal plate morphology	J:171906
	abnormal forelimb morphology	J:133634
	abnormal hindlimb morphology	J:133634
	abnormal long bone epiphyseal plate proliferative zone	J:171906
	decreased fetal size	J:171906
	micromelia	J:171906
	short femur	J:171906
	short humerus	J:133634
	short limbs	J:133634
	short radius	J:133634
	short ulna	J:133634
	normal skeleton phenotype	J:171906
	vertebral body hypoplasia	J:171906
Col2a1Rgsc856/Col2a1Rgsc856 involves: C57BL/6JJcl * DBA/2JJcl	abnormal chondrocyte morphology	J:171906
	abnormal chondrocyte physiology	J:171906
	abnormal epiphyseal plate morphology	J:171906
	abnormal long bone epiphyseal plate proliferative zone	J:171906
	abnormal pelvic girdle bone morphology	J:171906
	abnormal skeleton morphology	J:171906
	abnormal vertebrae morphology	J:171906
	brachydactyly	J:171906
	decreased fetal size	J:171906
	perinatal lethality, complete penetrance	J:171906
	platyspondylia	J:171906
	short limbs	J:171906
	short snout	J:171906
Col2a1sedc/Col2a1sedc involves: C57BL/6J	abnormal digestive system physiology	J:85735
	decreased body length	J:85735
	decreased body weight	J:85735
	disorganized retina layers	J:85735
	head bobbing	J:85735
	impaired hearing	J:85735
	seizures	J:85735
	spinning	J:85735
Col2a1tm1.1Ksec/Col2a1+ involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	cyclopia	J:163739
	enophthalmos	J:163739
	microcephaly	J:163739
	midface hypoplasia	J:163739
Col2a1tm1.1Ksec/Col2a1+ involves: 129X1/SvJ * C57BL/6	abnormal forebrain development	J:163739
	abnormal head morphology	J:163739
	abnormal mesendoderm development	J:163739
	midface hypoplasia	J:163739
Col2a1tm1.1Ksec/Col2a1tm1.1Ksec involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	abnormal neural tube morphology	J:163739
	abnormal tail morphology	J:163739
	cyclopia	J:163739
	microcephaly	J:163739
	midface hypoplasia	J:163739
	prenatal lethality, incomplete penetrance	J:163739
Col2a1tm1.1Ksec/Col2a1tm1.1Ksec involves: 129X1/SvJ * C57BL/6	abnormal brain development	J:163739
	abnormal cranial ganglia morphology	J:163739
	abnormal diencephalon morphology	J:163739
	abnormal eye development	J:163739
	abnormal forebrain morphology	J:163739
	abnormal head morphology	J:163739
	abnormal mesendoderm development	J:163739
	abnormal optic vesicle formation	J:163739
	abnormal snout morphology	J:163739
	absent nasal cavity	J:163739
	absent nasal septum	J:163739
	cyclopia	J:163739
	enophthalmos	J:163739
	holoprosencephaly	J:163739
	maxilla hypoplasia	J:163739
	microcephaly	J:163739
	nasal bone hypoplasia	J:163739
	premaxilla hypoplasia	J:163739
	proboscis	J:163739
	retrognathia	J:163739
	short mandible	J:163739
	short snout	J:163739
Col2a1tm1.1Mcali/Col2a1tm1.1Mcali involves: 129S6/SvEvTac * C57BL/6J * FVB/N	no abnormal phenotype detected	J:184499
Col2a1tm1Dshh/Col2a1+ involves: 129S6/SvEvTac * C57BL/6J	no abnormal phenotype detected	J:212712
Col2a1tm1Dshh/Col2a1tm1Dshh involves: 129S6/SvEvTac * C57BL/6J	abnormal cartilage development	J:212712
	abnormal chest morphology	J:212712
	abnormal chondrocyte morphology	J:212712
	abnormal chondrocyte physiology	J:212712
	abnormal cranium morphology	J:212712
	abnormal endochondral bone ossification	J:212712
	abnormal long bone epiphyseal plate proliferative zone	J:212712
	abnormal pelvic girdle bone morphology	J:212712
	abnormal phalanx morphology	J:212712
	abnormal scapula morphology	J:212712
	abnormal skeleton development	J:212712
	abnormal thoracic cage morphology	J:212712
	abnormal trabecular bone morphology	J:212712
	abnormal vertebrae development	J:212712
	chondrodystrophy	J:212712
	cleft palate	J:212712
	cyanosis	J:212712
	decreased body length	J:212712
	decreased body size	J:212712
	decreased fetal size	J:212712
	decreased length of long bones	J:212712
	decreased width of hypertrophic chondrocyte zone	J:212712
	delayed endochondral bone ossification	J:212712
	disorganized long bone epiphyseal plate	J:212712
	distended abdomen	J:212712
	increased diameter of long bones	J:212712
	neonatal lethality, complete penetrance	J:212712
	respiratory distress	J:212712
	short facial bone	J:212712
	short femur	J:212712
	short humerus	J:212712
	short limbs	J:212712
	short snout	J:212712
Col2a1tm1Prc/Col2a1+ involves: 129/Sv * C57BL/6	abnormal anterior eye segment morphology	J:144313
	abnormal cartilage development	J:30041
	abnormal chondrocyte morphology	J:30041
	abnormal ciliary process morphology	J:144313
	abnormal lens morphology	J:144313
	abnormal posterior eye segment morphology	J:144313
	abnormal skeleton development	J:30041
	cleft palate	J:30041
	decreased body size	J:30041
	decreased fetal size	J:30041
	decreased hyaluronic acid level	J:144313
	neonatal lethality, incomplete penetrance	J:30041
	prominent forehead	J:30041
	short limbs	J:30041
	short snout	J:30041
	normal vision/eye phenotype	J:144313
Col2a1tm1Prc/Col2a1tm1Prc involves: 129	abnormal articular cartilage morphology	J:117910
	abnormal cartilage development	J:84739
	abnormal cartilage morphology	J:117910
	abnormal chest morphology	J:84739, J:117910
	abnormal endochondral bone ossification	J:84739, J:117910
	abnormal long bone epiphyseal plate morphology	J:117910
	abnormal long bone epiphysis morphology	J:117910
	abnormal long bone hypertrophic chondrocyte zone	J:84739, J:117910
	abnormal long bone metaphysis morphology	J:84739, J:117910
	abnormal long bone morphology	J:117910
	abnormal rib morphology	J:84739, J:117910
	abnormal skeleton development	J:84739
	abnormal trabecular bone morphology	J:117910
	abnormal vertebral body morphology	J:117910
	absent intervertebral disk	J:84739, J:117910
	chondrodystrophy	J:84739
	decreased body length	J:117910
	decreased embryo size	J:84739
	decreased length of long bones	J:84739, J:117910
	disorganized long bone epiphyseal plate	J:84739
	disproportionate dwarf	J:84739, J:117910
	domed cranium	J:117910
	enlarged vertebral body	J:84739, J:117910
	increased long bone epiphyseal plate size	J:84739
	persistence of notochord tissue	J:84739
	short facial bone	J:117910
	short mandible	J:117910
	short nasal bone	J:117910
Col2a1tm1Prc/Col2a1tm1Prc involves: 129/Sv * C57BL/6	abnormal bone marrow cavity morphology	J:30041
	abnormal cartilage development	J:30041, J:51376
	abnormal chondrocyte morphology	J:30041, J:51376
	abnormal heart valve morphology	J:30041
	abnormal limb bone morphology	J:30041
	abnormal long bone epiphysis morphology	J:30041
	abnormal pulmonary alveolus morphology	J:30041
	abnormal vertebral arch morphology	J:30041
	absent intervertebral disk	J:51376
	absent palatal shelf	J:30041
	cleft palate	J:30041
	decreased autopod size	J:30041
	decreased body size	J:30041
	decreased bone mineral density	J:30041
	decreased length of long bones	J:30041
	normal immune system phenotype	J:30041
	increased renal plasma flow rate	J:30041
	kidney hemorrhage	J:30041
	normal liver/biliary system phenotype	J:30041
	perinatal lethality, complete penetrance	J:30041
	persistence of notochord tissue	J:51376
	prominent forehead	J:30041
	respiratory distress	J:30041
	short facial bone	J:30041
	short limbs	J:30041
	short ribs	J:30041
	short snout	J:30041
	small cranium	J:30041
	normal vision/eye phenotype	J:30041
Tg(Col2a1*G574S)1Waho/0 involves: C57BL/6 * DBA/2	abnormal chondrocyte differentiation	J:38204
	abnormal cranium morphology	J:38204
	abnormal endochondral bone ossification	J:38204
	abnormal epiphyseal plate morphology	J:38204
	abnormal long bone epiphyseal plate morphology	J:38204
	abnormal long bone epiphyseal plate proliferative zone	J:38204
	abnormal long bone hypertrophic chondrocyte zone	J:38204
	abnormal thoracic cage morphology	J:38204
	cleft palate	J:38204
	decreased body size	J:38204
	decreased length of long bones	J:38204
	delayed endochondral bone ossification	J:38204
	distended abdomen	J:38204
	perinatal lethality, incomplete penetrance	J:38204
	short limbs	J:38204
	short snout	J:38204
	short tail	J:38204
	short vertebral column	J:38204
Tg(Col2a1*R789C)#Waho/0 involves: C57BL/6 * DBA/2	abnormal cartilage morphology	J:112540
	abnormal chest morphology	J:112540
	abnormal epiphyseal plate morphology	J:112540
	abnormal limb bone morphology	J:112540
	abnormal long bone epiphyseal plate proliferative zone	J:112540
	abnormal perichondrium morphology	J:112540
	cleft palate	J:112540
	decreased body length	J:112540
	decreased litter size	J:112540
	delayed bone ossification	J:112540
	disproportionate dwarf	J:112540
	distended abdomen	J:112540
	neonatal lethality, complete penetrance	J:112540
	protruding tongue	J:112540
	respiratory distress	J:112540
	short limbs	J:112540
	short ribs	J:112540
	short snout	J:112540
	short vertebral column	J:112540